Development of Externalizing Behavior Problems: Gene-Environment Interplay

外化行为问题的发展：基因与环境的相互作用

• 批准号: 8291203
• 负责人: Laura A Baker
• 金额: $ 72.58万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-05 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8291203
• 关键词: 18 year old; Address; Adolescence; Adolescent; Adult; Affect; Age; Aggressive behavior; Alcohol or Other Drugs use; Antisocial Personality Disorder; Behavior; Behavior assessment; Behavioral; Biological; Boxing; Candidate Disease Gene; Childhood; Data; Development; Disease; Disinhibition; Drops; Environment; Environmental Risk Factor; Etiology; Female; Funding; Future; Gender; Genes; Genetic; Growth; Individual; Investigation; Laboratories; Longevity; Measures; Mental Health; Mental disorders; Modeling; Nature; Neurocognitive; Outcome; Pattern; Phase; Play; Prevention; Preventive Intervention; Problem behavior; Process; Psychopathology; Psychophysiology; Public Health; Quantitative Genetics; Risk; Risk Factors; Sampling; Societies; Source; Specific qualifier value; Subgroup; Substance abuse problem; Testing; Time; Twin Multiple Birth; Twin Studies; anti social; base; cohort; cost; criminal offending; critical period; design; deviant; early childhood; early onset; emerging adult; externalizing behavior; genetic analysis; high risk; informant; instrument; life course persistent; male; neurophysiology; offender; peer; prospective; psychologic; psychopathic personality; social; trait; young adult

DESCRIPTION (provided by applicant): The present study is a continuation into adulthood of a major longitudinal twin study of aggression and antisocial behavior (ASB) and its social and biological risk factors (#MH58354) in a diverse urban sample. The first two funding periods provided comprehensive laboratory assessments of behavioral, neurocognitive, social and psychophysiological function, and multi-trait, multi-rater assessments of externalizing psychopathology during four waves of investigation when the twins were ages 9-10 (Wave 1) 11-13 (Wave 2), 14-16 (Wave 3) and 17-18 years old (Wave 4). Relationships of ASB with known risk factors (social and biological) were confirmed, and new relationships identified. The extent to which genetic and environmental factors affect ASB, its risk factors and their relationships has also been elucidated, with many findings shown to vary across gender, informant, definition of ASB, and age. We propose to extend the study to include an adult assessment at ages 19-23 (Wave 5), to obtain comprehensive measures of antisocial and aggressive behavior and their risk factors during a period of greatest risk for criminal offending, antisocial personality disorder and substance abuse. The primary aim of the next phase is to understand environmental, genetic, and phenotypic continuities in externalizing behavior problems and their biological and social risk factors through adulthood, including the prediction of adult outcomes from childhood and adolescent measures. Adding the adult assessment will yield the most comprehensive, prospective longitudinal data on externalizing behavior problems ever obtained in a genetically informative design. This five-wave, 15 year longitudinal twin study will provide the unique opportunity to understand how genes and environment combine and interact to produce antisocial outcomes from childhood to adulthood, and will greatly enhance our understanding of externalizing psychopathology and its heterogeneous developmental trajectories. Understanding gene-environment interplay in the development of externalizing psychopathology is of key importance to future intervention and prevention.

描述（由申请人提供）：本研究是在多元化的城市样本中延续了对侵略性和反社会行为（ASB）及其社会和生物风险因素（＃MH58354）的主要纵向双胞胎研究（ASB）的成年。前两个资金期间提供了对行为，神经认知，社会和心理生理学功能的全面评估，以及在四个调查浪潮中对外部心理病理学的多特征，多评价评估，当时双胞胎年龄在9-10岁（第1波1）11-13（波2）11-13（波2），14-16（波3），14-16（波3）和17-18岁（浪潮4）。确认了ASB与已知危险因素（社会和生物学）的关系，并确定了新的关系。遗传和环境因素影响ASB的程度，其风险因素及其关系的程度也得到了阐明，许多发现在性别，线人，ASB的定义和年龄之间有所不同。 我们建议将研究扩展，以包括19-23岁（第5波）的成人评估，以在最大的犯罪犯罪，反社会人格障碍和滥用毒品的风险中获得全面的反社会和侵略行为及其风险因素。下一阶段的主要目的是通过成年后的行为问题及其生物学和社会风险因素进行外在化的环境，遗传和表型连续性，包括预测儿童和青少年措施的成人结果。添加成人评估将产生有关在遗传信息丰富的设计中获得的外在行为问题的最全面，前瞻性的纵向数据。这项五波，15年的纵向双胞胎研究将提供独特的机会，以了解基因和环境如何结合和相互作用以产生从童年到成年的反社会结果，并将极大地增强我们对外部化精神病理学及其异质发展轨迹的理解。了解基因 - 环境在发展外在心理病理学发展方面的相互作用对于未来的干预和预防至关重要。