Apoe Status & Health Outcomes In Older Persons

载脂蛋白状态

• 批准号: 6969755
• 负责人: Jack M Guralnik
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6969755
• 关键词: aging; apolipoprotein E; behavioral /social science research tag; cardiovascular disorder; clinical research; cognition; disease /disorder proneness /risk; epidemiology; functional ability; gene environment interaction; genetic susceptibility; health behavior; human data; human genetic material tag; human mortality; human old age (65+); human tissue; longitudinal human study; outcomes research; physical fitness; protein structure function; socioenvironment

This study will evaluate participants in the MacArthur Study on Successful Aging to examine how Apolipoprotein E (ApoE) status influences cognitive and physical decline, cardiovascular disease incidence and mortality, and all-cause mortality in a representative sample of older persons who initially had high cognitive and physical functioning. The analyses are based on evidence suggesting that ApoE4 genotype is associated with increased risk for Alzheimer's disease, cardiovascular disease and longevity in general as well as more suggestive evidence that it may also be associated with more general risks for cognitive decline and functional disability. Data on ApoE genotype for the MacArthur Successful Aging cohort is being obtained through analyses of stored DNA samples. These samples were originally collected in 1988 at the beginning of the study. Previous analyses of collected blood and urine samples have included assays for cholesterol, DHEA-S, glycosylated hemoglobin, homocysteine and folic acid levels as well as urinary cortisol and catecholamines. Additional, existing information int he MacArthur database includes sociodemographic, health status, health behaviors, psychosocial characteristics and detailed assessments of both physical and cognitive functioning. Data are now available for an 8-year follow-up period (1988-1996), including detailed information on patterns of change in cognitive and physical functioning, prevalence and incidence of cardiovascular disease and overall mortality. Cohort diversity with respect to gender, ethnicity, educational attainment and behavioral characteristics such as individuals' health behaviors (e.g., exercise, smoking) also provides sufficient numbers of individuals for proposed analyses of possible ApoE interactions with these characteristics.

本研究将评估麦克阿瑟成功衰老研究的参与者，以最初认知能力较高的老年人为代表，探讨载脂蛋白 E (ApoE) 状态如何影响认知和身体衰退、心血管疾病发病率和死亡率以及全因死亡率和身体机能。这些分析基于的证据表明，ApoE4 基因型与阿尔茨海默病、心血管疾病和长寿的风险增加有关，并且更有暗示性的证据表明，它也可能与认知能力下降和功能障碍的更普遍的风险有关。麦克阿瑟成功衰老队列的 ApoE 基因型数据是通过分析储存的 DNA 样本获得的。这些样本最初是在 1988 年研究开始时收集的。先前对收集的血液和尿液样本的分析包括胆固醇、DHEA-S、糖化血红蛋白、同型半胱氨酸和叶酸水平以及尿皮质醇和儿茶酚胺的测定。此外，麦克阿瑟数据库中的现有信息包括社会人口统计、健康状况、健康行为、心理社会特征以及身体和认知功能的详细评估。现已提供 8 年随访期（1988-1996）的数据，包括有关认知和身体功能变化模式、心血管疾病患病率和发病率以及总体死亡率的详细信息。性别、种族、教育程度和行为特征（例如个体的健康行为（例如运动、吸烟））的队列多样性也为拟议的 ApoE 与这些特征相互作用的分析提供了足够数量的个体。