Use Of Self- And Proxy-report To Impute The Ability To W

使用自我报告和代理报告来估算 W 的能力

• 批准号: 7135633
• 负责人: Jack M Guralnik
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7135633
• 关键词: behavioral /social science research tag; chordate locomotion; clinical research; data collection methodology /evaluation; functional ability; gait; human subject; performance; person with disability

Clinical trials aimed at preventing the onset of disability in older persons will be done to test a variety of interventions in the future. For this work, it is critical to utilize disability outcomes that are reproducible, valid, and meaningful to clinicians as well as older persons themselves. The ability to walk 400 meters, as measured using an objective test of performance, has been proposed as an outcome that meets these criteria. In clinical trials, the inability to determine if an outcome event has occurred in a portion of the population is a serious problem that reduces the power of the study and results in loss of validity of the findings. This research will provide a method of imputing this outcome for clinical trial participants who are unable or refuse to come into the clinic to undergo the formal, objective 400 meter walk test. In this methodologic study, participants will be asked a series of self-report items and then receive the 400 meter walk test. A proxy will also be asked about the walking habits and abilities of the participant. Having this complete data, it will then be determined what self-report or proxy items, either alone or in combination, can be used to impute ability to walk 400 meters. A specific item, a subset of items, a scale, or expert adjudication of the whole battery of questions are potential ways to develop this imputation of actual ability to walk 400 m. This pilot study will make a number of contributions that will be of interest to the general geriatric community and will be critical to the development of a clinical trial of mobility disability prevention.

旨在防止老年人的残疾发作的临床试验将在未来测试各种干预措施。对于这项工作，使用对临床医生以及老年人本身的可再现，有效且有意义的残疾结果至关重要。已经提出，通过客观的性能测试来测量400米的行走能力，作为符合这些标准的结果。在临床试验中，无法确定在人群的一部分中是否发生了结果事件是一个严重的问题，可以降低研究的力量并导致调查结果有效性丧失。这项研究将为无法或拒绝进入诊所接受正式的400米步行测试的临床试验参与者提供这种结果的方法。在这项方法学研究中，将向参与者询问一系列自我报告项目，然后接受400米步行测试。还将询问代理参与者的步行习惯和能力。拥有此完整的数据，它将被确定单独或组合的自我报告或代理项目可用于估算400米的能力。整个问题的特定项目，一部分项目，量表或专家裁决是开发这种实际行走能力400 m的潜在方法。这项试点研究将做出许多贡献，这些贡献将引起普通老年社区的关注，对于开发临床预防临床试验至关重要。