Use Of Self- And Proxy-report On Ability To Walk 400M

使用自我和代理报告步行 400M 的能力

• 批准号: 6674340
• 负责人: Jack M Guralnik
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6674340
• 关键词: aging; clinical trials; data collection methodology /evaluation; disabling disease; disease /disorder prevention /control; functional ability; gait; geriatrics; human subject; patient oriented research

Clinical trials aimed at preventing the onset of disability in older persons will be done to test a variety of interventions in the future. For this work, it is critical to utilize disability outcomes that are reproducible, valid, and meaningful to clinicians as well as older persons themselves. The ability to walk 400 meters, as measured using an objective test of performance, has been proposed as an outcome that meets these criteria. In clinical trials, the inability to determine if an outcome event has occurred in a portion of the population is a serious problem that reduces the power of the study and results in loss of validity of the findings. This research will provide a method of imputing this outcome for clinical trial participants who are unable or refuse to come into the clinic to undergo the formal, objective 400 meter walk test. In this methodologic study, participants will be asked a series of self-report items and then receive the 400 meter walk test. A proxy will also be asked about the walking habits and abilities of the participant. Having this complete data, it will then be determined what self-report or proxy items, either alone or in combination, can be used to impute ability to walk 400 meters. A specific item, a subset of items, a scale, or expert adjudication of the whole battery of questions are potential ways to develop this imputation of actual ability to walk 400 m. This pilot study will make a number of contributions that will be of interest to the general geriatric community and will be critical to the development of a clinical trial of mobility disability prevention.

未来将进行旨在预防老年人残疾发生的临床试验，以测试各种干预措施。对于这项工作，利用对临床医生和老年人本身可重复、有效且有意义的残疾结果至关重要。步行 400 米的能力（通过客观性能测试测量）已被提议作为满足这些标准的结果。在临床试验中，无法确定部分人群中是否发生了结果事件是一个严重的问题，它会降低研究的力量并导致研究结果失去有效性。这项研究将为无法或拒绝进入诊所接受正式、客观的 400 米步行测试的临床试验参与者提供一种估算此结果的方法。在这项方法学研究中，参与者将被要求完成一系列自我报告项目，然后接受 400 米步行测试。代理人还将被询问参与者的步行习惯和能力。有了这些完整的数据，然后将确定哪些自我报告或代理项目（单独或组合）可用于估算步行 400 米的能力。特定项目、项目子集、量表或整个问题组的专家裁决是开发 400 m 实际步行能力估算的潜在方法。这项试点研究将做出许多贡献，这些贡献将引起广大老年人群体的兴趣，并且对于行动障碍预防临床试验的发展至关重要。