Aging Brain: DTI, Subcortical Ischemia and Behavioral

大脑老化：DTI、皮层下缺血和行为

• 批准号: 7069994
• 负责人: STEPHEN P SALLOWAY
• 金额: $ 5.82万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7069994
• 关键词: Alzheimer' s disease; aging; apolipoprotein E; behavior; behavior test; behavioral /social science research tag; cerebrovascular imaging /visualization; clinical research; cognition; dementia; diffusion magnetic resonance imaging; frontal lobe /cortex; human subject; neuropsychological tests; neuropsychology; white matter

DESCRIPTION (provided by applicant): We will use diffusion-tensor imaging (DTI) to investigate the relationship between frontal white matter integrity and executive function and behavior in patients with subcortical ischemic vascular disease (SIVD). SIVD is characterized by lacunar infarcts and deep white matter changes and can cause cognitive impairment, accounts for approximately 50% of vascular dementia cases, and is associated with impairment in executive cognition and behavior presumably due to interruption of frontal-subcortical circuits. Executive and behavioral impairment leads to functional decline in the elderly and may hasten conversion to dementia. The aims of this proposal are (1) to demonstrate loss of white matter integrity in patients with SIVD vs. normal elderly controls using DTI, (2) to demonstrate an association between frontal white matter integrity measured with DTI and executive cognition and behavioral functioning in SIVD vs. normal elderly, and (3) to use innovative DTI tractography tools to identify specific white matter pathways and determine their association with cognition and behavior, j We will recruit a subgroup of subjects with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy) - a relatively pure form of SIVD - to serve as a "gold standard" comparison group to strengthen confidence that any significant associations are related to SIVD vs. other pathology. Our focus on behavior and the use of DTI tractography to explore associations in discrete fiber tracts is novel. The results of this study will contribute to our understanding of the impact of frontal systems disruption on cognition and behavior in SIVD and other disorders affecting white matter. The results could lead to the use of DTI as a predictor of susceptibility to cerebrovascular injury and of conversion to dementia, and help develop DTI as an outcome measure in treatment trails aimed at reducing cerebrovascular risk. Further, Aim 3 will produce innovative automated tractography methods that could lead to the development of a normative map of white matter connectivity across the lifespan which could be used to detect the earliest signs of white matter disease.

描述（由申请人提供）：我们将使用弥散张量成像（DTI）来研究皮质下缺血性血管疾病（SIVD）患者额叶白质完整性与执行功能和行为之间的关系。 SIVD 的特点是腔隙性梗塞和深部白质变化，可导致认知障碍，约占血管性痴呆病例的 50%，并且与执行认知和行为障碍相关，可能是由于额叶皮质下回路中断所致。执行和行为障碍会导致老年人功能衰退，并可能加速痴呆症的转变。 该提案的目的是 (1) 使用 DTI 证明 SIVD 患者与正常老年人对照相比白质完整性的丧失，(2) 证明使用 DTI 测量的额叶白质完整性与执行认知和行为功能之间的关联j 我们将招募患有 CADASIL（脑常染色体显性遗传病）受试者亚组动脉病伴皮质下梗死和白质脑病）——一种相对纯粹的 SIVD 形式——作为“金标准”对照组，以增强人们对 SIVD 与其他病理学之间的任何显着关联的信心。 我们对行为的关注以及使用 DTI 纤维束成像来探索离散纤维束中的关联是新颖的。这项研究的结果将有助于我们了解额叶系统破坏对 SIVD 和其他影响白质的疾病的认知和行为的影响。研究结果可能导致使用 DTI 作为脑血管损伤易感性和痴呆转化的预测因子，并有助于将 DTI 开发为旨在降低脑血管风险的治疗试验中的结果衡量标准。此外，Aim 3 将产生创新的自动纤维束成像方法，从而开发出整个生命周期白质连接的规范图，可用于检测白质疾病的最早迹象。