Aging Brain: DTI, Subcortical Ischemia and Behavioral

大脑老化：DTI、皮层下缺血和行为

• 批准号: 7069994
• 负责人: STEPHEN P SALLOWAY
• 金额: $ 5.82万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7069994
• 关键词: Alzheimer' s disease; aging; apolipoprotein E; behavior; behavior test; behavioral /social science research tag; cerebrovascular imaging /visualization; clinical research; cognition; dementia; diffusion magnetic resonance imaging; frontal lobe /cortex; human subject; neuropsychological tests; neuropsychology; white matter

DESCRIPTION (provided by applicant): We will use diffusion-tensor imaging (DTI) to investigate the relationship between frontal white matter integrity and executive function and behavior in patients with subcortical ischemic vascular disease (SIVD). SIVD is characterized by lacunar infarcts and deep white matter changes and can cause cognitive impairment, accounts for approximately 50% of vascular dementia cases, and is associated with impairment in executive cognition and behavior presumably due to interruption of frontal-subcortical circuits. Executive and behavioral impairment leads to functional decline in the elderly and may hasten conversion to dementia. The aims of this proposal are (1) to demonstrate loss of white matter integrity in patients with SIVD vs. normal elderly controls using DTI, (2) to demonstrate an association between frontal white matter integrity measured with DTI and executive cognition and behavioral functioning in SIVD vs. normal elderly, and (3) to use innovative DTI tractography tools to identify specific white matter pathways and determine their association with cognition and behavior, j We will recruit a subgroup of subjects with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarction and leukoencephalopathy) - a relatively pure form of SIVD - to serve as a "gold standard" comparison group to strengthen confidence that any significant associations are related to SIVD vs. other pathology. Our focus on behavior and the use of DTI tractography to explore associations in discrete fiber tracts is novel. The results of this study will contribute to our understanding of the impact of frontal systems disruption on cognition and behavior in SIVD and other disorders affecting white matter. The results could lead to the use of DTI as a predictor of susceptibility to cerebrovascular injury and of conversion to dementia, and help develop DTI as an outcome measure in treatment trails aimed at reducing cerebrovascular risk. Further, Aim 3 will produce innovative automated tractography methods that could lead to the development of a normative map of white matter connectivity across the lifespan which could be used to detect the earliest signs of white matter disease.

描述（由申请人提供）：我们将使用扩散调节成像（DTI）来研究额叶缺血性血管疾病（SIVD）患者的额叶白质完整性与执行功能与行为之间的关系。 SIVD的特征是凹陷的梗塞和深层白质变化，可能导致认知障碍，约占血管痴呆病例的50％，并且与执行认知和行为的损害有关，可能是由于额叶额叶额叶的中断。行政和行为障碍会导致老年人的功能下降，并可能加快转变为痴呆症。 The aims of this proposal are (1) to demonstrate loss of white matter integrity in patients with SIVD vs. normal elderly controls using DTI, (2) to demonstrate an association between frontal white matter integrity measured with DTI and executive cognition and behavioral functioning in SIVD vs. normal elderly, and (3) to use innovative DTI tractography tools to identify specific white matter pathways and determine their association with cognition and behavior, j We will recruit患有CADASIL的受试者（脑常染色体显性的动脉炎和皮质下梗死和白细胞核病）的亚组 - 一种相对纯净的SIVD形式 - 作为“金标准”比较组，以增强任何重要关联与SIVD与SIVD相关的信心。 我们对行为和使用DTI拖拉术在离散纤维区域探索关联的关注是新颖的。这项研究的结果将有助于我们理解额叶系统破坏对SIVD认知和行为的影响以及影响白质的其他疾病。结果可能导致DTI用作脑血管损伤和转化为痴呆的易感性的预测指标，并有助于发展DTI作为旨在减少脑血管风险的治疗踪迹的结果。此外，AIM 3将产生创新的自动拖拉学方法，这可能会导致整个生命周期中白质连通性的规范图的发展，该图可用于检测最早的白质疾病迹象。