EARLY MARKERS OF ALZHEIMER DISEASE

阿尔茨海默病的早期标志

• 批准号: 6431407
• 负责人: Alan B Zonderman
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6431407
• 关键词: Alzheimer's disease; age difference; brain mapping; brain metabolism; cerebrovascular imaging /visualization; clinical research; diagnosis design /evaluation; disease /disorder proneness /risk; estrogens; female; gender difference; hormone therapy; human middle age (35-64); human old age (65+); human subject; longitudinal human study; magnetic resonance imaging; memory; nervous system disorder diagnosis; nervous system disorder epidemiology; neuropsychological tests; pathologic process; positron emission tomography

Summary of work: Alzheimer's disease (AD) is the most widespread among several neurological degenerative diseases (dementias) that occur principally at later ages, occasionally before 60, but more frequently after age 70. This study examines prospective psychological, neurological, and neuropsychological changes in participants from the Baltimore Longitudinal Study of Aging (BLSA). Neurological and neuropsychological examinations are administered to participants aged 60 and older, repeating many of the tests that were administered to these subjects at earlier ages. Diagnoses of probable Alzheimer's disease follow the NINCDS-ADRDA criteria. In a recent publication, we showed that incidence rates of Alzheimer's disease from the Baltimore Longitudinal Study are consistent with published incidence rates despite its lack of representativeness. In this study, there were 1,236 participants (802 men, 434 women) with longitudinal follow-ups between January 1985 and May 1998. The average length of follow-up was 7.5 years, with participants evaluated every 2 years by physical, neurologic, and neuropsychological examinations. We diagnosed 155 cases of dementia and Alzheimer's disease based on criteria from the Diagnostic and Statistical Manual of Mental Disorders and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association. Of the 155 cases of dementia, there were 114 (74%) cases of Alzheimer's disease. Incidence rates of Alzheimer's disease increased with age from an estimated 0.08% per year (95% CI 0.00 to 0.43) in the 60 to 65 age group to an estimated 6.48% per year (95% CI 5.01 to 8.38) in the 85+ age group for men and women combined. The doubling time of incidence rates was approximately 4.4 years. There was a trend for women to have higher incidence rates than men and for an association of fewer years of education with higher incidence rates; but these effects were not significant. The median time of conversion from mild cognitive impairment to diagnosis of Alzheimer's disease was 4.4 years. These results suggest that the incidence rates for Alzheimer's disease in the Baltimore Longitudinal Study are consistent with published rates in other studies.

工作总结：阿尔茨海默病 (AD) 是几种神经退行性疾病（痴呆）中最常见的一种，主要发生在较晚的年龄，偶尔在 60 岁之前发生，但更常见于 70 岁之后。本研究考察了前瞻性的心理、神经和神经心理学变化巴尔的摩老龄化纵向研究 (BLSA) 的参与者。对 60 岁及以上的参与者进行神经学和神经心理学检查，重复对这些受试者早期进行的许多测试。可能的阿尔茨海默病的诊断遵循 NINCDS-ADRDA 标准。在最近的一份出版物中，我们表明，巴尔的摩纵向研究中的阿尔茨海默病发病率与已公布的发病率一致，尽管缺乏代表性。在这项研究中，有 1,236 名参与者（802 名男性，434 名女性）在 1985 年 1 月至 1998 年 5 月期间进行了纵向随访。随访的平均时间为 7.5 年，每 2 年对参与者进行一次身体、神经系统和神经心理学检查。我们根据《精神疾病诊断和统计手册》以及国家神经和交流障碍研究所以及中风-阿尔茨海默病和相关疾病协会的标准诊断了 155 例痴呆症和阿尔茨海默病病例。在 155 例痴呆症病例中，有 114 例（74%）患有阿尔茨海默病。阿尔茨海默病的发病率随着年龄的增长而增加，从 60 至 65 岁年龄组的估计每年 0.08%（95% CI 0.00 至 0.43）增加到 85 岁以上年龄组的估计每年 6.48%（95% CI 5.01 至 8.38）男女混合组。发病率翻倍的时间约为4.4年。女性的发病率有高于男性的趋势，而且受教育年限越少，发病率越高；但这些影响并不显着。从轻度认知障碍转变为阿尔茨海默病诊断的中位时间为 4.4 年。这些结果表明，巴尔的摩纵向研究中阿尔茨海默病的发病率与其他研究中公布的发病率一致。