Early Markers of Alzheimer Disease

阿尔茨海默病的早期标志

• 批准号: 8552327
• 负责人: Alan B Zonderman
• 金额: $ 49.99万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8552327
• 关键词: Age; Aging; Alzheimer' s Disease; Attention; Autopsy; Baltimore; Cognitive; Collaborations; Degenerative Disorder; Dementia; Diagnosis; Disease; Enrollment; Family; Home environment; Impaired cognition; Individual; Language; Learning; Longitudinal Studies; Measures; Memory; Mental Depression; Mission; National Institute on Aging; Neurologic; Participant; Performance; Prospective Studies; Research; Risk Factors; Role; Sampling; Semantic memory; Sorting - Cell Movement; Testing; Time; Visit; aged; base; case control; cognitive function; depressive symptoms; executive function; indexing; mental state; neuropathology; neuropsychological; prospective; psychologic; sex; visual memory

The Baltimore Longitudinal Study of Aging (BLSA) was established in 1958 and is one the oldest prospective studies of aging in the USA and the world. The mission of the BLSA is to learn what happens to people as they get old and how to sort out changes due to aging and from those due to disease or other causes. Most of our analyses examine the trajectories of performance levels over time. However, we have suspected that there is important information in the inconsistencies in performance, and that greater within individual variability might be associated with subsequent cognitive impairment and dementia. In a case-control sample of Baltimore Longitudinal Study of Aging (mean SD age = 69.90 8.92) participants, we matched 135 clinically diagnosed demented participants with 135 non-demented participants based on age at initial testing and sex. Cognitive performance was examined using measures of memory, executive function, attention, language, and global mental status performance from initial assessment to 5 years before cognitive impairment (mean assessments = 3.03). Compared with unimpaired individuals, individuals diagnosed with dementia had greater variability on measures of attention, executive function, language, and semantic memory at least 5 years before the estimated onset of cognitive impairment, which may indicate maladaptive cognitive functioning. The dementia cases, however, had less variability on visual memory than the unimpaired group, which may suggest that these cases had more difficulty learning. These results suggest that performance variability indexed over annual or biennial visits may be useful in identifying early signs of subsequent cognitive impairment.

巴尔的摩老龄化纵向研究 (BLSA) 成立于 1958 年，是美国和世界上最古老的老龄化前瞻性研究之一。 BLSA 的使命是了解人们变老时会发生什么，以及如何解决因衰老以及因疾病或其他原因引起的变化。 我们的大多数分析都会检查绩效水平随时间的变化轨迹。然而，我们怀疑表现的不一致存在重要信息，并且更大的个体差异可能与随后的认知障碍和痴呆有关。在巴尔的摩纵向衰老研究（平均 SD 年龄 = 69.90 ± 8.92）参与者的病例对照样本中，我们根据初始测试时的年龄和性别将 135 名临床诊断的痴呆参与者与 135 名非痴呆参与者进行匹配。使用记忆、执行功能、注意力、语言和整体心理状态表现的测量来检查认知表现，从最初评估到认知障碍发生前 5 年（平均评估 = 3.03）。与未受损的个体相比，被诊断患有痴呆症的个体在估计认知损伤发生前至少 5 年在注意力、执行功能、语言和语义记忆方面有更大的变异性，这可能表明认知功能适应不良。然而，痴呆症病例的视觉记忆变异性小于未受损组，这可能表明这些病例的学习困难更大。这些结果表明，每年或每两年访问一次的表现变异性可能有助于识别随后认知障碍的早期迹象。