Alzheimer's Disease Neuroimaging Initiative

阿尔茨海默病神经影像计划

• 批准号: 7596019
• 负责人: MICHAEL W WEINER
• 金额: $ 200万
• 依托单位: NORTHERN CALIFORNIA INSTITUTE/RES/EDU
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7596019
• 关键词: Accounting; Age; Aging; Alzheimer' s Disease; Archives; Attention; Biological Markers; Biostatistics Core; Blood; Brain; Brain Mapping; Clinical; Clinical Data; Clinical Trials; Clinical Trials Design; Clinical assessments; Cognition; Cognitive; Collaborations; Data; Data Analyses; Data Collection; Databases; Diagnostic; Disadvantaged; Elderly; Future; General Population; Generations; Goals; Hippocampus (Brain); Image; Impaired cognition; Informatics; Internet; Laboratories; Language; Lead; Link; Magnetic Resonance Imaging; Manufacturer Name; Measures; Medial; Memory; Metabolism; Methods; Modification; Monitor; Motion; Noise; Numbers; Patients; Pennsylvania; Photons; Positron-Emission Tomography; Prevention; Process; Rate; Recording of previous events; Research Design; Research Personnel; Resolution; Risk; Sample Size; Sampling; Scanning; Site; Staging; Standards of Weights and Measures; Statistical Models; Structure; Supervision; Techniques; Temporal Lobe; Testing; Time; TimeLine; Universities; Urine; Validation; Week; age effect; attenuation; base; brain volume; clinical research site; cognitive function; computerized data processing; cooperative study; cost effectiveness; day; design; entorhinal cortex; executive function; experience; fluorodeoxyglucose positron emission tomography; follow-up; frontal lobe; image processing; improved; instrumentation; mild neurocognitive impairment; neuroimaging; normal aging; programs; regional difference; repository; response; size; statistics; time interval; tool; treatment effect; treatment trial; willingness

INTRODUCTION: The Introduction portion of this proposal provides a general overview of the entire proj ect including Aims, Background, Preliminary results, and our Methodological approach. Our overall strategy to achieving the goals of the Alzheimer's Disease Neuroimaging Initiative (ADNI) are described, as well as a specific plan for implementation including governance structure, deliverables and timelines. ADMINISTRATIVE CORE: The Administrative Core, is directed by Dr. Michael Weiner, PI of the entire ADNI application, based at UCSF. This Core will be responsible for overseeing all aspects of the entire ADNI including the monitoring all financial and budetary aspects of the project. INFORMATICS CORE: The Informatics Core (IC), based at the Laboratory ofNeuroimaging (LONI) at UCLA will be directed by Dr. Arthur Toga. The IC will be responsible for receving, archiving, and displaying all MRI and PET data including all raw and processed data. All of this data will be available to ADNI investigators, and to the general public within weeks-months after receipt. The IC also describes a number of informatics and image processing and image display tools which will be used by the ADNI. Finally, the IC describes mechanisms by which clinical and cognitive data, stored at the UCSD ADCS group will be linked to the image data at LONI. This will facilitate queries and analyses which utilize clinical, cognitive, and imaging data. All raw and processed image data, as well as all clinical and biomarker data, will rapidly be made avialable on public websites. BIOSTATISTICS CORE: The Biostatistics Core (BC) will be directed by Dr. Laurel Beckett at UC Davis, and will consist of statisticans at UCSD and UCSF as well. The BC will implement mechanisms for data monitoring as data is acquired, to identify outliers and errrors. In addition, the BC describes a statistical approach to analyze data acquired by the ADNI, in order to test the apriori hypotheses described in the proposal, and presents a power analysis to justify the proposed sample size.

简介：本提案的简介部分提供了整个项目的总体概述 包括目标、背景、初步结果和我们的方法。我们的总体战略是 描述了实现阿尔茨海默病神经影像计划 (ADNI) 的目标，以及 具体实施计划，包括治理结构、可交付成果和时间表。 行政核心：行政核心由整个 ADNI 的 PI Michael Weiner 博士指导 应用程序，位于加州大学旧金山分校。该核心将负责监督整个 ADNI 的各个方面，包括 监督项目的所有财务和预算方面。 信息学核心：信息学核心 (IC)，位于加州大学洛杉矶分校神经影像实验室 (LONI) 将由阿瑟·托加博士执导。 IC 将负责接收、存档和显示所有 MRI PET 数据，包括所有原始数据和处理后的数据。所有这些数据都将提供给 ADNI 调查人员，并 收到后数周至数月内向公众公布。 IC 还描述了许多信息学和图像 ADNI 将使用的处理和图像显示工具。最后，IC 通过以下方式描述了机制： 存储在 UCSD ADCS 小组的临床和认知数据将与 LONI 的图像数据相关联。这 将促进利用临床、认知和成像数据的查询和分析。所有原料和加工品 图像数据以及所有临床和生物标志物数据将很快在公共网站上提供。 生物统计学核心：生物统计学核心 (BC) 将由加州大学戴维斯分校的 Laurel Beckett 博士指导， 也将由加州大学圣地亚哥分校和加州大学旧金山分校的统计学家组成。 BC 将实施数据监控机制 获取数据以识别异常值和错误。此外，BC 还描述了一种分析数据的统计方法 ADNI 获得的，为了测试提案中描述的先验假设，并提出一个权力 分析以证明建议的样本量的合理性。