The Mobile Toolbox for Monitoring Cognitive Function - Project

用于监测认知功能的移动工具箱 - 项目

• 批准号: 10212850
• 负责人: MICHAEL W WEINER
• 金额: $ 93.72万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212850
• 关键词: Adult; Age; Alzheimer' s Disease; Android; Assessment tool; Brain Health Registry; Calibration; Cellular Phone; Clinical; Cognition; Cognitive; Computer software; Computers; Consent; Custom; Data; Data Analyses; Data Collection; Diagnostic; Disease; Emotions; Ethnic Origin; General Population; Geography; Goals; Gold; Health; Health Status; Impaired cognition; Intelligence; Internet; Libraries; Longevity; Measures; Methodology; Methods; Monitor; Moods; Neuropsychological Tests; Parkinson Disease; Participant; Patient Self-Report; Personality; Procedures; Property; Protocols documentation; Psychometrics; Public Domains; Questionnaires; Race; Registries; Research; Research Personnel; Research Project Grants; Resources; Respondent; Risk; Sampling; Self Administration; Series; Testing; United States National Institutes of Health; Validation; Withdrawal; base; biological sex; cognitive ability; cognitive change; cognitive function; cognitive task; cognitive testing; data management; demographics; design; flexibility; follow up assessment; follow-up; healthy aging; innovation; instrument; mobile application; programs; public repository; response; theories; validation studies

Project Summary Our research project will be a collaborative effort supported by all of the MobileToolbox Cores. The project will function as the vehicle within which we develop and psychometrically evaluate our cognitive assessment tools. We will do this by accomplishing the following specific aims. Aim 1: We will develop a repository of public-domain cognitive ability measures that enhance the assessment of cognitive change across the lifespan by enabling self-administered testing via iOS and Android smartphones. The MobileToolbox measures will be designed around the technical specifications of a flexible and open software platform that enables external researchers to customize use of the mobile app to fit the needs of their studies. Researchers will be able to choose from a diverse selection of cognitive measures, including several cognitive tasks highly sensitive to change, along with measures of contextual variables of relevance to cognitive functioning (e.g., mood, personality, health status). Aim 2: Evaluate the psychometric properties of MobileToolbox instruments through implemention of a series of data collection protocols aimed at calibration, norming, and face-to-face validation against existing gold standards. We will calibrate Item Response Theory based measures by administering them to a large (N=4,800) general population calibration sample. All newly developed MobileToolbox measures will be validated against existing gold standards in a sample of healthy adults ages 20-85. The validation protocol will include face-to-face administration of the NIH Toolbox Cognition Battery, core sub-tests of the Wechsler Adult Intelligence Scale (WAIS-IV), and additional tests as needed. During this cross-sectional validation session, respondents (N=260) will complete the self-administered MobileToolbox via smartphone in an un-proctored setting. Additional validation will be undertaken in existing clinical (e.g., cognitively impaired, Parkinson’s disease) and general population (e.g. Healthy Aging Study, N=100,000) samples. Finally, we will identify normative values for the MobileToolbox measures using a large, nationally-representative sample (N=6,800). Sub-samples of respondents will be used to identify normative cognitive change by completing 3-, 12- and 24- month follow-up assessments.

项目概要 我们的研究项目将是所有 MobileToolbox 核心支持的协作努力。 作为我们开发和心理测量评估我们的认知评估工具的工具。 我们将通过实现以下具体目标来做到这一点。 目标 1：我们将开发一个公共领域认知能力测量存储库，以增强 通过 iOS 进行自我管理测试，评估整个生命周期的认知变化 MobileToolbox 措施将围绕 Android 智能手机的技术规范进行设计。 灵活开放的软件平台，使外部研究人员能够定制移动应用程序的使用以适应 研究人员将能够从多种认知测量中进行选择， 包括一些对变化高度敏感的认知任务，以及对变化的上下文变量的测量 与认知功能的相关性（例如情绪、性格、健康状况）。 目标 2：通过实施评估 MobileToolbox 工具的心理测量特性 旨在校准、标准化和面对面验证的一系列数据收集协议 我们将通过管理它们来校准基于项目反应理论的措施。 大型 (N=4,800) 一般人群校准样本 所有新开发的 MobileToolbox 测量都将被采用。 验证方案将根据现有的黄金标准在 20-85 岁的健康成年人样本中进行验证。 包括 NIH 工具箱认知电池的面对面管理、韦克斯勒成人的核心子测试 智力量表 (WAIS-IV) 以及根据需要进行的其他测试 在此横断面验证过程中， 受访者 (N=260) 将在无人监考的情况下通过智能手机完成自我管理的 MobileToolbox 将在现有临床环境中进行额外验证（例如认知障碍、帕金森病）。 疾病）和一般人群（例如健康老龄化研究，N=100,000）样本最后，我们将识别。 MobileToolbox 测量的标准值使用具有全国代表性的大型样本 (N=6,800)。 受访者的子样本将用于通过完成 3-、12- 和 24- 来识别规范性认知变化 月跟踪评估。