Mentoring the next generation of substance use, HIV, and epigenetic researchers in sexual and gender minority health

指导下一代性和性别少数健康领域的药物滥用、艾滋病毒和表观遗传学研究人员

• 批准号: 10699933
• 负责人: Annesa Flentje
• 金额: $ 19.71万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699933
• 关键词: Acceleration; Accounting; Age; Aging; All of Us Research Program; American; Animal Model; Applications Grants; Area; Award; Behavioral Sciences; Bioinformatics; Biological; Biological Markers; Biology; California; Cessation of life; Clinical Psychology; Cohort Studies; Community Health Systems; Consent; Data; Data Set; Discipline; Discrimination; Emotional; Environment; Epigenetic Process; Estrogens; Faculty; Foundations; Funding; Gender; Goals; Gonadal Hormones; HIV; Health; Heterosexuals; Hormonal; Hormones; Human; Hydrocortisone; Immune response; Injury; K-Series Research Career Programs; Lesbian Gay Bisexual Transgender Queer; Longitudinal cohort study; Measures; Mentors; Mentorship; Metabolic; Modeling; Molecular Profiling; Outcome; Ovariectomy; Participant; Persons; Phenotype; Progesterone; Proxy; Psychiatry; Reproducibility; Research; Research Personnel; Resources; Risk; Safety; Sampling; San Francisco; Sexual and Gender Minorities; Stress; Structure; Surveys; Testing; Testosterone; Training; Training Programs; United States; United States National Institutes of Health; Universities; Variant; Work; career; cisgender; comorbidity; disability; epigenetic marker; epigenome; epigenomics; family building; gender affirming hormones; gender minority group; gender minority health; health disparity; improved; innovation; interest; marijuana use; mid-career faculty; minority stress; minority stressor; molecular marker; next generation; non-heterosexual; nonbinary; patient oriented; phenotypic biomarker; physical conditioning; programs; research study; response; sex; sex assigned at birth; sexual minority men; skills; social stigma; stressor; substance use; substance use treatment; systematic review; transgender

ABSTRACT Dr. Annesa Flentje is Associate Professor in Community Health Systems and Department of Psychiatry and Behavioral Sciences at the University of California, San Francisco. She mentors early career researchers in sexual and gender minority (SGM, non-heterosexual and transgender or gender non-binary people, respectively) health, focusing on substance use, minority stress, and epigenomic markers of substance use. SGM people have greater substance use when compared to their cisgender, heterosexual counterparts. The greater rates of substance use are attributed to minority stress exposure (unique stress burden due to discrimination and stigma among SGM people), and substance use increases in the presence of minority stress. Further, unique molecular profiles of both substance use and minority stress have been observed in sexual minority men living with HIV, suggesting that alterations in the epigenome may serve as biological markers for substance use. Unfortunately, research to date is limited because these models have not explicitly compared people living with HIV (PLWH) and people living without HIV (PLWoH). Further, SGM people have unique hormonal exposures that have been unaccounted for in research investigating substance use and potential epigenetic biomarkers for substance use and these hormonal exposures may also be related to alterations in the epigenome. This project will expand Dr. Flentje’s research program to integrate hormonal exposures and HIV status, to be able to identify epigenomic markers of substance use in the presence of endogenous and exogenous hormone exposures comparing PLWH to PLWoH. To support expansion of her research, Dr. Flentje will receive additional training in HIV, hormone exposures, dominance analysis, and epigenetic bioinformatics analysis. This K24 will support Dr. Flentje in mentoring patient-oriented researchers in SGM health who will leverage survey and epigenetic data from existing cohort studies: The PRIDE Study, the MACS/WIHS Combined Cohort Study, and the All of Us Research Program to 1) understand key minority stress predictors of substance use among SGM people and compare the relative strength of these predictors between PLWH and PLWoH; 2) identify endogenous and exogenous hormonal predictors of substance use among SGM people and determine differences in the relative strength of these predictors among PLWH and PLWoH; and 3) derive minority stress, substance use, and hormonal phenotypes among SGM people, identify epigenetic markers of these phenotypes, and identify differences in these epigenetic markers between PLWH and PLWoH. This K24 will support mentorship of early career researchers in SGM health focusing on substance use, HIV, hormonal biology, epigenomics, and minority stress. It will also expand Dr. Flentje’s mentorship skills to integrate structures to support mentees in navigating financial challenges, loan repayment applications, family building, and emotional hardships. As substance use research among SGM people is an emerging area of study, a national approach to mentorship to promote innovation in patient-centered research is critical.

抽象的 Annesa Flentje 博士是社区卫生系统和精神病学系副教授 她在旧金山加利福尼亚大学行为科学领域指导早期职业研究人员。 性少数群体和性别少数群体（分别为 SGM、非异性恋者和跨性别者或非二元性别人士） 健康，重点关注物质使用、少数族裔压力和物质使用的表观基因组标记。 与同性、异性相比，他们的物质使用率更高。 物质使用归因于少数人的压力暴露（由于歧视和耻辱而产生的独特压力负担） SGM 人群中），并且在少数族裔压力存在的情况下物质使用会增加。此外，独特的分子压力。 在感染艾滋病毒的性少数男性中观察到物质使用和少数压力的概况， 不幸的是，表观基因组的改变可以作为物质使用的生物标志物。 迄今为止的研究还很有限，因为这些模型没有明确比较艾滋病毒感染者 (PLWH) 此外，SGM 人群还具有独特的荷尔蒙暴露水平。 在调查物质使用和物质使用的潜在表观遗传生物标志物的研究中下落不明 这些激素暴露也可能与表观基因组的改变有关。 Flentje 的研究计划整合激素暴露和 HIV 状况，以便能够识别表观基因组 比较 PLWH 在内源性和外源性激素暴露情况下物质使用的标志物 为了支持扩大她的研究，Flentje 博士将接受艾滋病毒、激素方面的额外培训。 该 K24 将为 Flentje 博士提供支持。 指导 SGM 健康领域以患者为中心的研究人员，他们将利用现有的调查和表观遗传学数据 队列研究：PRIDE 研究、MACS/WIHS 联合队列研究和 All of Us 研究计划 1) 了解 SGM 人群中物质使用的关键少数压力预测因素，并比较相对 PLWH 和 PLWoH 之间这些预测因素的强度；2) 确定内源性和外源性激素 SGM 人群中物质使用的预测因子，并确定这些物质使用的相对强度的差异 PLWH 和 PLWoH 的预测因子；3) 得出少数群体压力、物质使用和激素表型 在 SGM 人群中，识别这些表型的表观遗传标记，并识别这些表型的差异 PLWH 和 PLWoH 之间的表观遗传标记该 K24 将支持早期职业研究人员的指导。 SGM 健康中心还将重点关注药物滥用、艾滋病毒、激素生物学、表观基因组学和少数族裔压力。 扩展 Flentje 博士的指导技能，整合结构以支持受训者应对财务挑战 挑战、贷款偿还申请、家庭建设和情感困难作为药物使用研究。 SGM 的一个新兴研究领域是一个全国性的指导方法，以促进创新 以患者为中心的研究至关重要。