4.7 T Small Aninal MR Imaging and Spectroscopy System

4.7T小型动物磁共振成像及光谱系统

• 批准号: 6501291
• 负责人: JONATHAN S LEWIN
• 金额: $ 132.5万
• 依托单位: UNIVERSITY HOSPITALS OF CLEVELAND
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至 2006-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6501291
• 关键词: Rodentias; biomedical equipment purchase; magnetic resonance imaging; spectrometry

DESCRIPTION (provided by applicant): We request a 4.7T horizontal bore small animal multinuclear MR imaging and spectroscopy system, hereafter referred to as the small animal MRVS system, for in vivo cellular and molecular imaging. This system will be an integral part of our plan to create a multi-institutional, Ohio Cellular and Molecular Imaging Consortium (OCMIC). This plan to develop small animal imaging with multiple imaging resources builds on existing expertise in genetics and small animal models of disease, cancer biology, and neuroscience, as well as imaging technology. The OCMIC will be developed using funds from this and various related proposals. The successful utilization of the requested small animal-MRVS system is made possible by many faculty dedicated to its use and by two existing development awards to Case Western Reserve University (CWRU). The first is a Whitaker Development Award extension that includes three new faculty members in small animal imaging, including a new person in MR contrast agents. These new faculty members will supplement existing faculty members in imaging who have skills in MR imaging, image analysis, and contrast agent design. The second is an NIH funded P20 planning grant to create an In Vivo Cellular and Molecular lmaging Center (pre-ICMIC). There is wide interdisciplinary support from the CWRU Schools of Medicine, Engineering, and Arts and Sciences. There is no existing in vivo microscopic MRI system in all of Northern Ohio and we intend to make this system available to many committed researchers through the OCMIC. Potential users have been identified at University Hospitals of Cleveland, Case Western Reserve University, Cleveland Clinic Foundation, and Cleveland State University. Numerous PIs have been identified and sample research projects are in the areas of cancer, neuroscience, tissue engineering, and cardiovascular research. A rational plan for administration of the project builds on our experience with a Cancer Center Core facility consisting of a dual photon confocal microscope and a vertical bore 7.0T NMR system that will be upgraded to be suitable for imaging of excised tissue. The OCMIC and pre-ICMIC will provide a framework for growing the user base to include a large number of existing NIH funded researchers. With institutional cash commitments of $758,500, in addition to non-cash commitments and other proposals related to this project, we have a sound financial plan for success.

描述（由申请人提供）：我们要求4.7吨水平钻孔小动物多核MR成像和光谱系统，以下称为小动物MRVS系统，用于体内细胞和分子成像。 该系统将是我们计划创建多机构的俄亥俄细胞和分子成像联盟（OCMIC）的计划的组成部分。 该计划开发具有多种成像资源的小动物成像的计划基于遗传学，疾病，癌症生物学和神经科学的小动物模型以及成像技术的现有专业知识。 OCMIC将使用该建议和各种相关建议的资金开发。 许多专门用于其使用的教师以及两个现有的开发奖颁发给Case Western Reserve University（CWRU），因此成功利用了所需的小型动物MRVS系统。 第一个是Whitaker Development奖的扩展，其中包括三个小型动物成像中的新教师，包括MR造影剂中的一个新人。这些新的教职员工将补充现有的教职员工成像，他们在MR成像，图像分析和对比代理设计方面具有技能。 第二个是由NIH资助的P20计划赠款，以创建体内细胞和分子LMAGGING CENTER（ICMIC）。 CWRU医学，工程以及艺术与科学学院得到了广泛的跨学科支持。 在俄亥俄州北部，没有现有的体内微观MRI系统，我们打算通过OCMIC使许多忠实的研究人员可以使用该系统。 潜在用户已在克利夫兰大学医院，凯斯西部储备大学，克利夫兰诊所基金会和克利夫兰州立大学确定。 已经确定了许多PI，样本研究项目在癌症，神经科学，组织工程和心血管研究领域。 该项目给药的合理计划是基于我们在癌症中心核心设施中的经验，该设施由双光子共聚焦显微镜和垂直孔7.0T NMR系统组成，该系统将升级为适合于切除组织的成像。 OCMIC和ICMIC将为种植用户群提供一个框架，以包括大量现有的NIH资助研究人员。 除了与该项目相关的非现金承诺和其他建议外，我们还拥有一项合理的成功计划。