MR GUIDED THERMAL ABLATION OF ABDOMINAL TUMORS

MR 引导腹部肿瘤热消融

• 批准号: 6276530
• 负责人: JONATHAN S LEWIN
• 金额: $ 1.83万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276530
• 关键词: abdomen neoplasm; clinical research; human subject; human therapy evaluation; magnetic resonance imaging; metastasis; neoplasm /cancer thermotherapy; abdomen neoplasm; clinical research; human subject; human therapy evaluation; magnetic resonance imaging; metastasis; neoplasm /cancer thermotherapy

The objectives of this trial are: to describe the safety of Magnetic Resonance (MR) guided thermal ablation of soft tissue metastases and to describe the fraction of tumor necrosis that can be generated within tumors through thermal ablation using a radiofrequency (RF) generator as the heat source. Patients are only those with solid tumors that have failed intervention with standard measures or those for which systemic therapy was considered ineffective. Patients must not be candidates for surgical resection. There have been eight patients treated (11 enrollments). Three patients were enrolled for ablation of different lesions. To date one subject achieved a complete response, five enrollments had stable disease, three developed progressive disease, one patient was cancelled and the last has not been analyzed.

该试验的目标是：描述磁性的安全性 共振（MR）指导软组织转移的热消融和到 描述可以在内部产生的肿瘤坏死的分数 使用射频（RF）发电机通过热消融的肿瘤 作为热源。 患者只有患有实体瘤的患者 对标准措施或系统性的措施的干预失败 治疗被认为无效。患者不能成为候选人 手术切除。 有8例接受治疗的患者（11名入学人数）。 三个患者 被招募用于消融不同的病变。 迄今为止一个主题 达成了完全反应，五个入学率患有稳定的疾病， 三个发达的进行性疾病，一名患者被取消，该患者 最后尚未分析。