Quantitative Oncologic PET-MR

定量肿瘤学 PET-MR

基本信息

批准号：
8451303
负责人：
Georges El Fakhri
金额：
$ 46.79万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8451303
关键词：
Abdomen Air Anatomy Animal Model Animals Breathing Cancer Patient Chemoembolization Chest Clinical Colorectal Cancer Communities Data Detection Disease Dose Event Fatty acid glycerol esters Financial compensation Goals Gold Hepatitis Viruses Hour Image Information Theory Lesion Liver Lung Magnetic Resonance Imaging Malignant Neoplasms Maps Measures Medical Medical Imaging Metastatic Neoplasm to the Liver Methods Metric Modeling Monitor Motion Musculoskeletal Noise Oryctolagus cuniculus PET/CT scan Pelvis Performance Positron-Emission Tomography Primary carcinoma of the liver cells Primates Radiation Radiofrequency Interstitial Ablation Recording of previous events Recovery Recurrence Recurrent disease Research Resolution Scientist System Testing Time Tissues Tumor Markers Woodchuck attenuation base bone cancer therapy chemotherapy experience human subject image registration imaging modality improved interest novel radiologist reconstruction respiratory response simulation soft tissue statistics theories vector

项目摘要

DESCRIPTION (provided by applicant): The goals of this research are to develop novel quantitative methods for simultaneous whole- body (WB) PET-MR imaging, validate these methods in a woodchuck model of spontaneous hepatocellular carcinoma and evaluate their clinical value, compared to PET-CT, in monitoring response to therapy in liver metastases. Simultaneous PET-MR is a novel and promising imaging modality that is generating substantial interest in the medical community and offers the scientific community many challenges and opportunities. Unlike sequentially- acquired WB PET-CT scans, the simultaneous acquisition of MR and PET data can be used to incorporate MR motion and anatomical MR priors within the PET reconstruction model. We hypothesize that the additional MR information will yield substantial improvement of PET in terms of lesion detection and activity estimation. We have formed a multi-disciplinary team that consists of scientists and clinicians to develop quantitative methods for PET-MR and evaluate clinically the improvement that can be achieved over conventional sequential PET-CT.

描述（由申请人提供）：本研究的目标是开发同步全身 (WB) PET-MR 成像的新颖定量方法，在自发性肝细胞癌土拨鼠模型中验证这些方法，并评估其临床价值，与PET-CT，用于监测肝转移治疗的反应。同步 PET-MR 是一种新颖且有前途的成像方式，引起了医学界的极大兴趣，并为科学界提供了许多挑战和机遇。与顺序采集的 WB PET-CT 扫描不同，同时采集 MR 和 PET 数据可用于将 MR 运动和解剖 MR 先验合并到 PET 重建模型中。我们假设额外的 MR 信息将在病变检测和活动估计方面显着改进 PET。我们组建了一个由科学家和临床医生组成的多学科团队来开发定量 PET-MR 方法，并在临床上评估相对于传统序贯 PET-CT 可以实现的改进。