Memorial Sloan Kettering Small Animal Imaging Research

纪念斯隆凯特琳小动物成像研究

• 批准号: 6941739
• 负责人: JASON Arthur KOUTCHER
• 金额: $ 74.5万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941739
• 关键词: Rodentias; autoradiography; bioimaging /biomedical imaging; biomedical equipment development; biomedical equipment purchase; biomedical equipment resource; computed axial tomography; drug screening /evaluation; image processing; neoplasm /cancer radioimmunotherapy; neoplasm /cancer radionuclide diagnosis; nuclear magnetic resonance spectroscopy; optical tomography; positron emission tomography; radiopharmacology; radiotracer; single photon emission computed tomography; training

DESCRIPTION (provided by applicant): Research at Memorial Sloan Kettering Cancer Center is focused on cancer diagnosis and enhancing response to treatment. Because tumors are heterogeneous, both between individuals and within a single tumor, non-invasive imaging studies are necessary to provide information about variations in response. The main technologies we will focus on include nuclear magnetic resonance (NMR), positron emission tomography (PET), and optical imaging, although other instruments are part of the application. The 3 imaging techniques chosen were based on the fact that they will provide complementary information. NMR imaging provides high spatial resolution but modest functional data. PET and NMR spectroscopy have poorer spatial resolution but provide valuable chemical/metabolic information. Optical imaging can provide very sensitive imaging tools to detect very small numbers of cells and thus these modalities have different strengths. We focus on enhancing the ancillary/support services to maximize information available from the different studies. Image analysis/correlation is important since in most studies, multiple imaging studies are done and it is critical to spatially align different or longitudinal studies. The Synthetic Chemistry and Vector Cores are critical for developing novel tools for exploring signaling pathways, and molecular events related to oncogenesis, treatment, cell death and host toxicity. Enhancement of imaging techniques to maintain state of the art methodologies, improving current techniques, and converting imaging into a more quantitative science is vital. A wide range of oncologic issues will be studied to exploit these tools in developing newer and better targeted drugs, to minimize host toxicity, to develop standards of response criteria for cytostatic drugs and detect responses/failures earlier in the course of treatment. The range of projects studied include predicting tumor response to treatment, dosimetry for radioimmunotherapy, pharmacology, gene therapy and imaging, tumor metabolism, and evaluating responses to novel cytostatic agents. Research at MSKCC is translational and the goals of many of these projects are to be moved to the clinic in the shortest time feasible. Leadership will come from the imaging scientists (Drs. Koutcher, Blasberg and Larson) and also from the molecular pharmacology group who will meet monthly along with a Technology Committee, to decide which problems are important and appropriate to be addressed by imaging technology.

描述（由申请人提供）：纪念斯隆凯特琳癌症中心的研究重点是癌症诊断和增强治疗反应。由于肿瘤在个体之间和单个肿瘤内都是异质的，因此有必要进行非侵入性成像研究以提供有关反应变化的信息。我们将重点关注的主要技术包括核磁共振 (NMR)、正电子发射断层扫描 (PET) 和光学成像，尽管其他仪器也是该应用的一部分。选择 3 种成像技术是基于它们将提供补充信息这一事实。核磁共振成像提供高空间分辨率但功能数据有限。 PET 和 NMR 光谱的空间分辨率较差，但可以提供有价值的化学/代谢信息。光学成像可以提供非常灵敏的成像工具来检测极少量的细胞，因此这些模式具有不同的优势。我们专注于加强辅助/支持服务，以最大限度地利用不同研究提供的信息。图像分析/相关性很重要，因为在大多数研究中，都会进行多项成像研究，并且在空间上对齐不同或纵向研究至关重要。合成化学和载体核心对于开发探索信号通路以及与肿瘤发生、治疗、细胞死亡和宿主毒性相关的分子事件的新工具至关重要。增强成像技术以保持最先进的方法、改进现有技术并将成像转化为更加定量的科学至关重要。将研究广泛的肿瘤学问题，以利用这些工具开发更新和更好的靶向药物，最大限度地减少宿主毒性，制定细胞抑制药物的反应标准，并在治疗过程的早期检测反应/失败。研究项目范围包括预测肿瘤对治疗的反应、放射免疫治疗的剂量测定、药理学、基因治疗和成像、肿瘤代谢以及评估对新型细胞抑制剂的反应。 MSKCC 的研究是转化性的，其中许多项目的目标是在最短的可行时间内转移到临床。领导层将来自成像科学家（Koutcher、Blasberg 和 Larson 博士）以及分子药理学小组，他们将与技术委员会一起每月举行一次会议，以决定哪些问题是重要且适合通过成像技术解决的。