ANIMAL IMAGING

动物成像

基本信息

批准号：
7671810
负责人：
JASON Arthur KOUTCHER
金额：
$ 13.64万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-31 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7671810
关键词：
Animals Area Arts Autoradiography Bioluminescence Capital Detection Development Disease Disease regression Disseminated Malignant Neoplasm Effector Cell Equipment Evaluation Film Floor Fluorescence Fluorescent Probes Gene Expression Genetic Housing Human Hypoxia Image Imaging Techniques Immune Improve Access Incidence Intervention Invasive Knock-out Laboratory Research Localized Longitudinal Studies Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Neoplasms Memorial Sloan-Kettering Cancer Center Metabolic Microtome - medical device Modality Modeling Modernization Monitor Numbers Optical Tomography Optics Patients Pharmacodynamics Phase Photons Positron Process Radioisotopes Radiolabeled Reporter Genes Research Research Infrastructure Research Personnel Resolution Rodent Rodent Model Screening procedure Services Spectrum Analysis Staging Stem cells System Testing Tracer Transgenic Organisms Tumor Biology Ultrasonography Validation X-Ray Computed Tomography Xenograft Model base biosecurity cancer cell digital disease natural history fluorescence microscope host neoplasm interaction in vivo insight instrumentation molecular imaging neoplastic cell optical imaging radiotracer single photon emission computed tomography spectroscopic imaging tomography trafficking tumor tumor initiation

Animals Area Arts Autoradiography Bioluminescence Capital Detection Development Disease Disease regression Disseminated Malignant Neoplasm Effector Cell Equipment Evaluation Film Floor Fluorescence Fluorescent Probes Gene Expression Genetic Housing Human Hypoxia Image Imaging Techniques Immune Improve Access Incidence Intervention Invasive Knock-out Laboratory Research Localized Longitudinal Studies Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Neoplasms Memorial Sloan-Kettering Cancer Center Metabolic Microtome - medical device Modality Modeling Modernization Monitor Numbers Optical Tomography Optics Patients Pharmacodynamics Phase Photons Positron Process Radioisotopes Radiolabeled Reporter Genes Research Research Infrastructure Research Personnel Resolution Rodent Rodent Model Screening procedure Services Spectrum Analysis Staging Stem cells System Testing Tracer Transgenic Organisms Tumor Biology Ultrasonography Validation X-Ray Computed Tomography Xenograft Model base biosecurity cancer cell digital disease natural history fluorescence microscope host neoplasm interaction in vivo insight instrumentation molecular imaging neoplastic cell optical imaging radiotracer single photon emission computed tomography spectroscopic imaging tomography trafficking tumor tumor initiation

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项目摘要

The Animal Imaging Core provides services for molecular imaging of rodent models of human cancer. The Core provides investigators with non-invasive, high-resolution quantitative imaging-based capabilities for metabolic and genetic characterization of tumors and their microenvironment, including in vivo trafficking of tumor cells. This is accomplished by monitoring of "directly-targeting" probes and of the expression of single and multi-modality reporter genes using optical (bioluminescence and fluorescence), radionuclide (PET, SPECT, and autoradiography), MRI/MRS, CT, and US imaging. These imaging techniques are wellestablished at MSKCC for small-animal imaging studies. They are quantitative and non-invasive and thus readily adaptable to longitudinal studies. The Animal Imaging Core also provides investigators with access to critical ancillary equipment and services such as a Fuji Film BAS-180011 phosphor-plate digital autoradiography system, a digital-camera-equipped Olympus B 201 fluorescence microscope with motorized stage, and a Microm HM500M cryostatic microtome. As part of a major expansion and modernization of MSKCC's infrastructure (Phase 1), part of the Imaging Core has recently re-located to the C4 level within the Vivarium of the new Zuckerman Research Center. This area provides enhanced biosecurity and functionality and houses our R4 and Focus 120 microPET dedicated high-resolution small-animal (rodent) PETs, new MS 200 optical imaging system, microCAT II dedicated small-animal (rodent) CT, and X-SPECT dedicated small-animal SPECT-CT. The existing MS 100 optical imaging system and recently installed Vevo 770 ultrasound system have been re-located to refurbished space on the 12th floor of the Rockefeller Research Laboratory providing improved access to the primary users of these two systems. The Imaging Core's 4.7-T 40-cm bore and 7.0-T 31-cm Brucker NMR imaging and spectroscopy systems are currently located in the MRI Building. In Phase 2 of MSKCC's capital expansion and modernization, all of the foregoing instrumentation of the Imaging Core will be consolidated in spacious, state-of the-art quarters with the Center's vivarium.

动物成像核心为人类癌症啮齿动物模型的分子成像提供服务。核心为研究人员提供了非侵入性，高分辨率基于定量成像的功能用于肿瘤及其微环境的代谢和遗传表征，包括体内贩运肿瘤细胞。这是通过监视“直接靶向”探针和表达来实现的使用光学（生物发光和荧光），放射性核素的单模式报告基因（PET，SPECT和自显影），MRI/MRS，CT和US成像。这些成像技术是很好的在MSKCC进行小动物成像研究。它们是定量和无创的，因此容易适应纵向研究。动物成像核心还为调查人员提供了访问关键的辅助设备和服务，例如富士胶片BAS-180011磷光板数字放射自显影系统，配备数字相机的Olympus B 201荧光显微镜机动阶段和Microm HM500M低温固化微型群。作为MSKCC基础架构的重大扩展和现代化的一部分（第1阶段），成像的一部分 Core最近已将新Zuckerman Research Center的Vivarium内的C4水平重新定位为C4水平。该区域提供了增强的生物安全性和功能，并容纳了我们的R4和Focus 120 Micropet 专用的高分辨率小动物（啮齿动物）宠物，新的MS 200光学成像系统，Microcat II 专用的小动物（啮齿动物）CT和X-spect专用的小动物SPECT-CT。现有的MS 100个光学成像系统和最近安装的VEVO 770超声系统已重新定位为洛克菲勒研究实验室12楼的翻新空间，可改善进入这两个系统的主要用户。 Imaging Core的4.7-T 40厘米孔和7.0-T 31厘米布鲁克 NMR成像和光谱系统目前位于MRI建筑物中。在MSKCC的第二阶段资本扩张和现代化，所有前述成像核心的工具都是与中心的Vivarium合并在宽敞的，最先进的区域。