MR-PET for a Small Animal Imaging Center

用于小动物成像中心的 MR-PET

• 批准号: 7854793
• 负责人: JASON Arthur KOUTCHER
• 金额: $ 76.9万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7854793
• 关键词: Acute; Animals; Antibodies; Area; Arts; Biochemical; Biochemistry; Biological Markers; Biology; Biomedical Research; Biopsy; Blood flow; Caliber; California; Cancer Patient; Cardiac; Caring; Chemistry; Cherry - dietary; Clinic; Collaborations; Contrast Media; Data; Detection; Development; Diagnosis; Drug Kinetics; Electronics; Equipment; Functional Imaging; Funding; Gases; Glycolysis; Goals; Grant; Heterogeneity; Hypoxia; Image; Infectious Agent; Inhalation Anesthesia; Institution; Interdisciplinary Study; Kinetics; Label; Laboratories; Lead; Letters; Lung; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Maps; Measures; Memorial Sloan-Kettering Cancer Center; Metabolism; Methods; Modality; Monitor; Morbidity - disease rate; Mus; Mutation; Nature; Peer Review; Peer Review Grants; Peptide antibodies; Performance; Perfusion; Physiologic pulse; Physiological; Positron-Emission Tomography; Principal Investigator; Process; Production; Prognostic Marker; Radiochemistry; Radioisotopes; Radiolabeled; Radiopharmaceuticals; Rattus; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resistance; Resolution; Resources; Risk; Sampling Errors; Scientist; System; Techniques; Technology; Temperature; Testing; Time; Translating; Translations; United States National Institutes of Health; Universities; Virus; anticancer research; cancer care; cancer therapy; comparative; design; environmental change; fluorodeoxyglucose positron emission tomography; imaging modality; improved; innovation; instrument; instrumentation; metabolic abnormality assessment; molecular imaging; neoplastic; novel; novel marker; oncology; public health relevance; radiofrequency; radiotracer; respiratory; response; response marker; skills; small molecule; spectroscopic imaging; tumor; uptake

DESCRIPTION (provided by applicant): This application, for a Research and Research Infrastructure "Grand Opportunities" (GO) grant (RFA- OD-09-004) will focus on "Comparative Oncology Research" and requests funds for a unique state of the art PET insert for an MR animal scanner which will be used by numerous biomedical research laboratories as an open scientific resource, with a major impact on translational oncology research. There are 30 principal investigators and 37 peer reviewed research projects supported by this application including projects from 9 institutions outside MSKCC. Simultaneous acquisition of PET and MR data will be used for studies of novel dual MR-PET contrast agents, concurrent kinetics, biochemical studies of metabolism, and to study the distribution of labeled antibodies and the effects of hypoxia, tumor perfusion heterogeneity on uptake, targeting and efficacy. Many physiological phenomena (such as hypoxia, perfusion, pharmacokinetics) undergo acute changes, vary from animal to animal, and contrast/radiotracer agent uptake and distribution may depend on different time varying physiological parameters so simultaneous acquisition is critical. Our collaboration with Dr. Cherry envisages construction of a PET insert for MSKCC, and we will provide NMR (lactate pulse sequences, quantitation, radiofrequency coils) and chemistry expertise. We will evaluate the effect of the PET insert on MR image and spectral quality at both 4.7T and 7T and the effect of both magnets on PET performance and provide this data to Dr. Cherry. We will improve and develop novel pulse sequences for lactate detection and imaging which will be used frequently with concurrent fluorodeoxyglucose (FDG) PET scanning since both are measuring different aspects of glycolysis and are markers of prognosis. A critical development will be an isolation chamber in order to allow investigators from many institutions to use the imaging equipment and minimize the risk of cross contamination of animals from different institutions. This chamber is designed to isolate the animal from the scanner and will have ports for respiratory, temperature and cardiac monitoring to decrease morbidity and improve image quality, in addition to a port for inhalation anesthesia and other gases. MSKCC is a world leader in development and translation of radiolabeled small molecules, peptides and antibodies for the imaging and therapy of cancer. We have access to a broad gamut of radionuclides for PET studies and the chemistry expertise to dual label them with 19F, Fe or Gd to produce agents that can be visualized by both MR and PET. We will develop the isolation chamber, lactate detection methods, and novel dual modality contrast agents prior to the delivery of the PET insert for immediate use upon delivery. The MR-PET scanner will support 37 different projects that will yield significant benefit form this research. This project will be started immediately if funded and enhance multidisciplinary research and interactions between investigators of broadly different background, thereby leading to new breakthroughs in cancer care. PUBLIC HEALTH RELEVANCE: Relevance This application, for a Research and Research Infrastructure "Grand Opportunities" (GO) grant (RFAOD- 09-004) will focus on "Comparative Oncology Research" and requests funds for a unique state of the art Positron Emission Tomography (PET) insert for an MR animal scanner which will be used by numerous biomedical research laboratories as an open scientific resource, with a major impact on translational cancer research.

描述（由申请人提供）：本研究基础设施“大机遇”(GO) 拨款 (RFA-OD-09-004) 申请将重点关注“比较肿瘤学研究”，并要求为该研究的独特状态提供资金。用于 MR 动物扫描仪的 art PET 插件将被众多生物医学研究实验室用作开放科学资源，对转化肿瘤学研究产生重大影响。该申请支持了 30 名主要研究者和 37 个同行评审的研究项目，其中包括来自 MSKCC 以外的 9 个机构的项目。同时采集PET和MR数据将用于新型双MR-PET造影剂的研究、同时动力学、代谢生化研究，以及研究标记抗体的分布以及缺氧、肿瘤灌注异质性对摄取、靶向的影响和功效。许多生理现象（例如缺氧、灌注、药代动力学）会经历剧烈变化，因动物而异，造影剂/放射性示踪剂的摄取和分布可能取决于不同时间变化的生理参数，因此同时采集至关重要。 我们与 Cherry 博士的合作设想为 MSKCC 构建 PET 插入物，我们将提供 NMR（乳酸脉冲序列、定量、射频线圈）和化学专业知识。我们将评估 PET 插入物在 4.7T 和 7T 下对 MR 图像和光谱质量的影响以及两种磁铁对 PET 性能的影响，并将这些数据提供给 Cherry 博士。我们将改进和开发用于乳酸检测和成像的新型脉冲序列，这些脉冲序列将经常与同步氟脱氧葡萄糖 (FDG) PET 扫描一起使用，因为两者都测量糖酵解的不同方面，并且是预后的标志。一个关键的发展将是一个隔离室，以便允许来自许多机构的研究人员使用成像设备，并最大限度地减少来自不同机构的动物交叉污染的风险。该室旨在将动物与扫描仪隔离，除了用于吸入麻醉剂和其他气体的端口外，还将具有用于呼吸、温度和心脏监测的端口，以降低发病率并提高图像质量。 MSKCC 是开发和翻译用于癌症成像和治疗的放射性标记小分子、肽和抗体的世界领先者。我们可以获得用于 PET 研究的广泛放射性核素，并拥有化学专业知识，可以用 19F、Fe 或 Gd 对它们进行双重标记，以生产可通过 MR 和 PET 可视化的试剂。我们将在 PET 插入物交付之前开发隔离室、乳酸检测方法和新型双模态造影剂，以便在交付后立即使用。 MR-PET 扫描仪将支持 37 个不同的项目，这些项目将从这项研究中产生显着的效益。如果获得资助，该项目将立即启动，并加强多学科研究以及背景广泛的研究人员之间的互动，从而在癌症治疗方面取得新的突破。 公共健康相关性：相关性 本申请针对研究和研究基础设施“大机遇”(GO) 拨款 (RFAOD-09-004)，将重点关注“比较肿瘤学研究”，并请求资金用于独特的最先进的正电子发射断层扫描MR 动物扫描仪的 (PET) 插入物将被众多生物医学研究实验室用作开放科学资源，对转化癌症研究产生重大影响。