9.4T/20 cm MRI for Cancer Research

用于癌症研究的 9.4T/20 cm MRI

• 批准号: 7389866
• 负责人: JASON Arthur KOUTCHER
• 金额: $ 50万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389866
• 关键词: Address; Adverse effects; Animals; Biological Models; Blood flow; Brain Neoplasms; Breast Sarcoma; Cancer Detection; Clinic; Clinical; Colon Carcinoma; Data; Development; Drug Delivery Systems; Ensure; Facility Construction Funding Category; Funding Mechanisms; Goals; Human; Hypoxia; Image; Magnetic Resonance Imaging; Methods; Monitor; Noise; Outcome; Oxygen; Peer Review Grants; Performance; Physiological; Policies; Prostate; Range; Research; Research Personnel; Resistance; Signal Transduction; System; Technology; Therapeutic; Toxic effect; Translating; United States National Institutes of Health; anticancer research; base; cancer care; design; drug metabolism; improved; in vivo; instrument; interstitial; oncology; pre-clinical; pressure; research study; response; tumor

DESCRIPTION (provided by applicant): The goal of this application is to obtain support for purchase of a 9.4T 20 cm bore horizontal NMR system for in vivo biomedical applications, focused on cancer research. There are 15 major users with 26 peer reviewed grants who will use the 7T and proposed 9.4T systems. There are a wide range of approaches to addressing different oncologic problems, including cancer detection, predicting tumor response, and developing methods of monitoring tumor and drug metabolism to enhance therapeutic outcomes. The projects are highly translational in that most of these methods can be translated to the clinic, based on the relatively common availability of 3T MRI systems, and the growing (although still limited) availability of human magnets at even higher field strengths. One can summarize the long range goal of these collectively diverse projects as the improvement of cancer care by enhancing responses without correspondingly increased toxicity, either by improving therapies or by development of early markers of response (or resistance) so as to avoid side effects from ineffective treatments. The design and methods of the different projects are diverse but common principles will maximize the data obtained from experiments on the proposed system. These methods include 1) continuing high throughput, relatively straightforward animal imaging research needed by numerous investigators on the existing 4.7T system which has a lower field strength but wide bore and can more readily accommodate multiple animals concurrently, 2) focus more demanding experiments on the 7T and proposed 9.4T systems, 3) where necessary, perform appropriate phantom and preliminary experiments to determine which NIH supported users' experiments will gain relatively more by use of the 9.4T vs the 7T system, 4) the use of statistically valid experimental groups and 5) continue our policy of trying to provide support to the various users in the design of experiments, construction of appropriate hardware, and if necessary, assisting in the performance of the experiments to ensure that they are performed in an optimized manner, with best signal to noise possible. The applications that will be supported on the proposed 9.4T instrument address a wide range of oncology problems, as reflected by the different funding mechanisms from which they arise. These include a focus on a wide spectrum of tumors (brain, prostate, breast, sarcomas, colon cancers), addressing varying relevant physiological problems in oncology (hypoxia (lack of oxygen), elevated tumor interstitial pressure leading to poor blood flow and drug delivery, the need for better tumor model systems, improvements in imaging etc). The approaches to addressing these problems are quite varied but have in common the feasibility to readily translate any of these findings from the preclinical to the clinical realm, based on existing technology.

描述（由申请人提供）：本申请的目的是获得购买9.4t 20 cm孔的水平NMR系统，用于体内生物医学应用，重点是癌症研究。有15个主要用户，有26个同行评审的赠款，他们将使用7T并提议的9.4T系统。解决不同的肿瘤问题，包括癌症检测，预测肿瘤反应以及开发监测肿瘤和药物代谢以增强治疗结果的方法。这些项目具有很高的转化，因为这些方法中的大多数可以根据3T MRI系统的相对常见的可用性以及在更高的田间强度下的人类磁铁的可用性（尽管仍然有限）转化为诊所。可以通过改善反应而没有相应增加毒性来改善癌症护理的远距离目标，以改善毒性，通过改善疗法或发展早期的反应（或抵抗）标记物（或抵抗），以避免对无效治疗的副作用。不同项目的设计和方法是多种多样的，但是共同的原理将最大化从建议系统上的实验获得的数据。这些方法包括1）众多研究人员对现有的4.7T系统所需的持续高通量，相对直接的动物成像研究，该系统具有较低的野外强度，但可以更容易地容纳多个动物，2）同时将更多的实验集中在7T和拟议的9.4T系统上，并在必要的情况下进行适当的实验，以确定相关的实验，以确定相关的实验，该实验的相关实验，该实验的实验，以实验，并确定phantom和prolimiar的实验。 9.4T与7T系统，4）使用统计有效的实验组和5）继续我们的政策，试图在设计时为各种用户提供支持，建造适当的硬件，并在必要时进行实验的执行，以确保它们以优化的方式执行，以最佳信号以最佳信号以噪音。所提出的9.4T仪器将支持的应用程序解决了各种肿瘤问题，这反映了它们出现的不同资金机制。其中包括关注广泛的肿瘤（大脑，前列腺，乳腺，肉瘤，结肠癌），以解决肿瘤学（缺氧（缺氧缺乏氧），肿瘤层压升高，导致血液流量较差和药物递送的肿瘤升高，对更好的肿瘤模型系统的需求，改善成像等的相关生理问题。解决这些问题的方法非常多样化，但通常可以根据现有技术将这些发现从临床前转换为临床领域的可行性。