MR-PET for a Small Animal Imaging Center

用于小动物成像中心的 MR-PET

• 批准号: 7943047
• 负责人: JASON Arthur KOUTCHER
• 金额: $ 77.42万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7943047
• 关键词: Acute; Animals; Antibodies; Area; Arts; Biochemical; Biochemistry; Biological Markers; Biology; Biomedical Research; Biopsy; Blood flow; Caliber; California; Cancer Patient; Cardiac; Caring; Chemistry; Cherry - dietary; Clinic; Collaborations; Contrast Media; Data; Detection; Development; Diagnosis; Drug Kinetics; Electronics; Equipment; Functional Imaging; Funding; Gases; Glycolysis; Goals; Grant; Heterogeneity; Hypoxia; Image; Infectious Agent; Inhalation Anesthesia; Institution; Interdisciplinary Study; Kinetics; Label; Laboratories; Lead; Letters; Lung; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Maps; Measures; Memorial Sloan-Kettering Cancer Center; Metabolism; Methods; Modality; Monitor; Morbidity - disease rate; Mus; Mutation; Nature; Peer Review; Peer Review Grants; Peptide antibodies; Performance; Perfusion; Physiologic pulse; Physiological; Positron-Emission Tomography; Principal Investigator; Process; Production; Prognostic Marker; Radiochemistry; Radioisotopes; Radiolabeled; Radiopharmaceuticals; Rattus; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resistance; Resolution; Resources; Risk; Sampling Errors; Scientist; System; Techniques; Technology; Temperature; Testing; Time; Translating; Translations; United States National Institutes of Health; Universities; Virus; anticancer research; cancer care; cancer therapy; comparative; design; environmental change; fluorodeoxyglucose positron emission tomography; imaging modality; improved; innovation; instrument; instrumentation; metabolic abnormality assessment; molecular imaging; neoplastic; novel; novel marker; oncology; public health relevance; radiofrequency; radiotracer; respiratory; response; response marker; skills; small molecule; spectroscopic imaging; tumor; uptake

DESCRIPTION (provided by applicant): This application, for a Research and Research Infrastructure "Grand Opportunities" (GO) grant (RFA- OD-09-004) will focus on "Comparative Oncology Research" and requests funds for a unique state of the art PET insert for an MR animal scanner which will be used by numerous biomedical research laboratories as an open scientific resource, with a major impact on translational oncology research. There are 30 principal investigators and 37 peer reviewed research projects supported by this application including projects from 9 institutions outside MSKCC. Simultaneous acquisition of PET and MR data will be used for studies of novel dual MR-PET contrast agents, concurrent kinetics, biochemical studies of metabolism, and to study the distribution of labeled antibodies and the effects of hypoxia, tumor perfusion heterogeneity on uptake, targeting and efficacy. Many physiological phenomena (such as hypoxia, perfusion, pharmacokinetics) undergo acute changes, vary from animal to animal, and contrast/radiotracer agent uptake and distribution may depend on different time varying physiological parameters so simultaneous acquisition is critical. Our collaboration with Dr. Cherry envisages construction of a PET insert for MSKCC, and we will provide NMR (lactate pulse sequences, quantitation, radiofrequency coils) and chemistry expertise. We will evaluate the effect of the PET insert on MR image and spectral quality at both 4.7T and 7T and the effect of both magnets on PET performance and provide this data to Dr. Cherry. We will improve and develop novel pulse sequences for lactate detection and imaging which will be used frequently with concurrent fluorodeoxyglucose (FDG) PET scanning since both are measuring different aspects of glycolysis and are markers of prognosis. A critical development will be an isolation chamber in order to allow investigators from many institutions to use the imaging equipment and minimize the risk of cross contamination of animals from different institutions. This chamber is designed to isolate the animal from the scanner and will have ports for respiratory, temperature and cardiac monitoring to decrease morbidity and improve image quality, in addition to a port for inhalation anesthesia and other gases. MSKCC is a world leader in development and translation of radiolabeled small molecules, peptides and antibodies for the imaging and therapy of cancer. We have access to a broad gamut of radionuclides for PET studies and the chemistry expertise to dual label them with 19F, Fe or Gd to produce agents that can be visualized by both MR and PET. We will develop the isolation chamber, lactate detection methods, and novel dual modality contrast agents prior to the delivery of the PET insert for immediate use upon delivery. The MR-PET scanner will support 37 different projects that will yield significant benefit form this research. This project will be started immediately if funded and enhance multidisciplinary research and interactions between investigators of broadly different background, thereby leading to new breakthroughs in cancer care. PUBLIC HEALTH RELEVANCE: Relevance This application, for a Research and Research Infrastructure "Grand Opportunities" (GO) grant (RFAOD- 09-004) will focus on "Comparative Oncology Research" and requests funds for a unique state of the art Positron Emission Tomography (PET) insert for an MR animal scanner which will be used by numerous biomedical research laboratories as an open scientific resource, with a major impact on translational cancer research.

描述（由申请人提供）：对于研究和研究基础架构“大机会”（GO）Grant（RFA-OD-09-004），该申请将重点放在“比较肿瘤学研究”上，并要求为MR动物扫描仪的独特艺术宠物插件提供资金，该MR动物扫描仪将被许多生物医学研究实验室用于开放科学的研究，并将其用于一项开放性的研究，并在coptical上进行了一项跨越的影响。该申请支持该应用程序的支持，包括30名主要研究人员和37个同行审查的研究项目，其中包括来自MSKCC以外的9个机构的项目。 PET和MR数据的同时获取将用于研究新型的双MR-PET对比剂，并发动力学，代谢的生化研究，并研究标记抗体的分布以及缺氧，肿瘤灌注异质性对摄取，靶向和效果的影响。许多生理现象（例如缺氧，灌注，药代动力学）发生急性变化，从动物到动物变化，对比/放射性示例剂的摄取和分布可能取决于不同的时间变化的生理参数，因此同时获得的获得至关重要。 我们与Cherry博士的合作设想为MSKCC建造宠物插入物，我们将提供NMR（乳酸脉冲序列，定量，射频线圈）和化学专业知识。我们将评估PET插入物对4.7T和7T的MR图像和光谱质量的影响，以及两种磁体对PET性能的影响，并将这些数据提供给Cherry博士。我们将改善并开发新的脉冲检测和成像脉冲序列，这些脉冲序列将经常与并发的氟脱氧葡萄糖（FDG）PET扫描一起扫描，因为两者都在测量糖酵解的不同方面，并且是预后的标志。关键的发展将是一个隔离室，以允许许多机构的调查人员使用成像设备，并最大程度地减少不同机构的动物交叉污染的风险。该腔室旨在将动物与扫描仪隔离开来，并具有用于呼吸道，温度和心脏监测的端口，以降低发病率并提高图像质量，此外还有吸入麻醉和其他气体的端口。 MSKCC是用于癌症成像和治疗的放射性标记的小分子，肽和抗体的发展和翻译的世界领导者。我们可以使用广泛的放射性核素进行宠物研究和化学专业知识，可以将它们与19F，Fe或GD搭配，以生产MR和PET可视化的剂。我们将在输送宠物插入物之前，在输送送货前立即使用隔离室，乳酸检测方法和新型的双态对比剂。 MR-PET扫描仪将支持37个不同的项目，这些项目将产生这项研究的重大收益。如果资助资金，将立即开始该项目，并增强背景不同的研究人员之间的多学科研究和相互作用，从而导致癌症护理的新突破。 公共卫生相关性：与研究和研究基础架构“大机会”（GO）Grant（RFAOD- 09-004）的相关性将重点放在“比较肿瘤学研究”上，并要求为一个独特的艺术表演层析成像（PET）插入的独特状态的MR Animal Scanner插入，该MR动物扫描将由许多生物领域的研究进行了一项开放式研究，以一项开放式的癌症进行了一项专业的研究。