4.7T MRI Scanner for Small Animal Imaging Applications

适用于小动物成像应用的 4.7T MRI 扫描仪

• 批准号: 6877482
• 负责人: Mary E. Meyerand
• 金额: $ 50万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877482
• 关键词: Rodentias; bioimaging /biomedical imaging; biomedical equipment purchase; health science research; magnetic resonance imaging; neoplasm /cancer; radiology

DESCRIPTION (provided by applicant): The adaptation of MRI technology to use in rodents represents an unprecedented opportunity to revolutionize the design and monitoring of animal models of disease. High-field, small-animal MRI allows visualization deep into structures and permits this visualization to be carried out over extended periods of time with no damage to the animal. The Specific Aim of this proposal is to acquire funds to purchase a 4.7 Tesla (T) Magnetic Resonance Imaging (MRI) scanner for imaging small animals (primarily rodents). With the Wisconsin Molecular Imaging Center (WIMIC), the University of Wisconsin (UW) Comprehensive Cancer Center and the Departments of Radiology, and Medical Physics, the UW has become a leader in MRI technique development and application to a wide variety of disease states and organ systems. However, these studies have been limited to using clinical MRI scanners. The quality of the data has been limited by the clinical gradient and RF hardware and therefore studies have been restricted to lower resolution studies (>0.25mm). Acquisition of a high-field MRI scanner will allow researchers involved in numerous projects to explore in vivo anatomy and physiology with unprecedented resolution (100 mu/m in-plane). A unique aspect of the work at the UW is the close linkage between basic scientists and clinicians. The data generated with a 4.7T MRI scanner will markedly enhance current scientific efforts with the resolution required to explore disease models in both mice and rats. These data will be critical in guiding and interpreting human MRI studies. The new high-field MRI scanner will be housed in the UW Comprehensive Cancer Center located in the UW Hospital. This location is ideal because it will be readily accessible to the many Cancer Center users and it will also be next door to the micro-CT scanner. Because CT and MRI are complementary modalities, we foresee many opportunities for studies to be moved between the two scanners. A dedicated scientific advisory committee, made up of prominent MRI imaging researchers and principle investigators who use small animal models, will provide the administrative, scientific, and technical expertise. Among the broad research areas represented by potential users of the system are: cardiac, renal and muscle physiology, zoology, biomedical engineering, developmental biology, oncology, neuroscience, oncology, pathology, and stem cell research. The research programs of many of these users will be advanced significantly if a high field MRI system is available to them. The acquisition of the 4.7T scanner will complement the existing micro-imaging resources on campus including micro-PET and micro-CT scanners, and it will open new avenues of investigation for biological and physical scientists from across the UW-Madison campus.

描述（由申请人提供）： 在啮齿动物中使用的MRI技术的适应是彻底改变疾病动物模型的设计和监测的前所未有的机会。高场，小动物MRI允许可视化到结构深处，并允许在长时间内进行这种可视化，而不会对动物造成损害。该提案的具体目的是获取资金以购买4.7 Tesla（T）磁共振成像（MRI）扫描仪用于成像小动物（主要是啮齿动物）。威斯康星州分子成像中心（WIMIC），威斯康星大学（UW）综合癌症中心和放射学系以及医学物理学部门，UW已成为MRI技术开发和应用于多种疾病状态和器官系统的领导者。但是，这些研究仅限于使用临床MRI扫描仪。数据的质量受到临床梯度和RF硬件的限制，因此研究仅限于较低的分辨率研究（> 0.25mm）。获得高场MRI扫描仪将使参与众多项目的研究人员可以以前所未有的分辨率（100 mU/m的平面内）探索体内解剖学和生理学。 UW的工作一个独特的方面是基础科学家与临床医生之间的紧密联系。用4.7T MRI扫描仪生成的数据将显着增强当前的科学努力，并通过探索小鼠和大鼠疾病模型所需的解决方案。这些数据对于指导和解释人类MRI研究至关重要。 新的高场MRI扫描仪将安置在西澳大学医院的UW综合癌症中心。这个位置是理想的选择，因为许多癌症中心用户很容易访问它，并且也将在Micro-CT扫描仪的隔壁。由于CT和MRI是互补的方式，因此我们预计在两个扫描仪之间进行研究的许多机会。一个专门的科学咨询委员会由使用小动物模型的著名MRI成像研究人员和主要研究人员组成，将提供行政，科学和技术专长。 该系统潜在用户代表的广泛研究领域包括：心脏，肾脏和肌肉生理学，动物学，生物医学工程，发育生物学，肿瘤学，神经科学，肿瘤学，病理学和干细胞研究。如果他们可以使用高现场MRI系统，那么许多用户的研究计划将得到显着提高。 4.7T扫描仪的获取将补充校园中现有的微型成像资源，包括微型PET和Micro-CT扫描仪，它将为来自UW-Madison校园的生物学和物理科学家开放新的调查途径。