In-Vivo Spectroscopy/Imaging System PharmaScan 47/16

体内光谱/成像系统 PharmaScan 47/16

基本信息

批准号：
6877430
负责人：
Natalie J. Serkova
金额：
$ 49.8万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2006-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6877430
关键词：
Rodentias bioimaging /biomedical imaging biomedical equipment purchase magnetic resonance imaging spectrometry

项目摘要

DESCRIPTION (provided by applicant): In this proposal we request funding for a Bruker 4.7/16 PharmaScan rodent MRI/MRS scanner. In the last decade, MRI and MRS (magnetic resonance imaging and spectroscopy) have shown great promise in drug discovery, basic pre-clinical investigations, as well as hypothesis-driven biomedical research. The advantages of these rapidly developing techniques are their non-invasive nature and the abundance of anatomical, physiological, and biochemical parameters that can be monitored. In the past year, the Department of Anesthesiology has established a Biomedical MRS laboratory with two high-resolution Bruker NMR systems (a 500 MHz narrow-bore and a 300 MHz wide-bore magnets) for ex vivo experiments on tissue extracts, cell cultures, and perfused organs. Although there is a high demand, the University of Colorado still does not have any MRS/MRI capabilities for animals; our existing imaging equipment is not sufficient to support the many needs of our investigators. UCHSC has several faculty members with extensive experience with animal MRI/MRS scanners who will be responsible for operation and maintenance of the requested PharmaScan. Specifically, having the first animal scanner at UCHSC, we will be able (a) to support all investigators of basic and translational research which is related to small animals; (b) to share imaging research resources to be used intradepartmentally and intrainstitutionally in Colorado; (c) to train both professional and technical support personnel in the science and techniques of small animal imaging; (d) to develop novel sophisticated methods in the area of molecular imaging. The requested PharmaScan will be placed in the MRS/MRI suite of the new Vivarium in Research Complex I on UCHSC's new Fitzsimons campus. This location will be ideal since animals will not have to be removed from the animal facility for MRS/MRI studies. The Departments of Anesthesiology, Pharmacology and the Cancer Center have committed sufficient financial resources for setting up, running and maintaining the instrument. This is a much needed instrumentation and will provide an important regional facility for in vivo research in Colorado and the surrounding Rocky Mountain region.

描述（由申请人提供）：在此提案中，我们请求资助 Bruker 4.7/16 PharmaScan 啮齿动物 MRI/MRS 扫描仪。在过去的十年中，MRI 和 MRS（磁共振成像和光谱学）在药物发现、基础临床前研究以及假设驱动的生物医学研究方面显示出了巨大的前景。这些快速发展的技术的优点是它们的非侵入性以及可以监测的丰富的解剖、生理和生化参数。去年，麻醉科建立了生物医学MRS实验室，配备两台高分辨率Bruker NMR系统（一台500 MHz窄孔磁体和一台300 MHz宽孔磁体），用于组织提取物、细胞培养、和灌注器官。尽管需求量很大，但科罗拉多大学仍然没有针对动物的 MRS/MRI 能力；我们现有的成像设备不足以满足我们研究人员的许多需求。 UHSC 拥有几位在动物 MRI/MRS 扫描仪方面拥有丰富经验的教员，他们将负责所需 PharmaScan 的操作和维护。具体来说，在 UHSC 拥有第一台动物扫描仪，我们将能够 (a) 支持与小动物相关的基础和转化研究的所有研究人员； (b) 共享科罗拉多州部门内和机构内使用的成像研究资源； (c) 对小动物成像科学技术方面的专业和技术支持人员进行培训； (d) 开发分子成像领域新颖的复杂方法。所请求的 PharmaScan 将放置在 UHSC 菲茨西蒙斯新校区 I 号研究中心新 Vivarium 的 MRS/MRI 套件中。该位置非常理想，因为无需将动物从动物设施中移出即可进行 MRS/MRI 研究。麻醉科、药理学科和癌症中心已投入足够的财政资源来安装、运行和维护该仪器。这是一种急需的仪器，将为科罗拉多州和周边落基山脉地区的体内研究提供重要的区域设施。