In-Vivo Spectroscopy/Imaging System PharmaScan 47/16

体内光谱/成像系统 PharmaScan 47/16

• 批准号: 6877430
• 负责人: Natalie J. Serkova
• 金额: $ 49.8万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877430
• 关键词: Rodentias; bioimaging /biomedical imaging; biomedical equipment purchase; magnetic resonance imaging; spectrometry

DESCRIPTION (provided by applicant): In this proposal we request funding for a Bruker 4.7/16 PharmaScan rodent MRI/MRS scanner. In the last decade, MRI and MRS (magnetic resonance imaging and spectroscopy) have shown great promise in drug discovery, basic pre-clinical investigations, as well as hypothesis-driven biomedical research. The advantages of these rapidly developing techniques are their non-invasive nature and the abundance of anatomical, physiological, and biochemical parameters that can be monitored. In the past year, the Department of Anesthesiology has established a Biomedical MRS laboratory with two high-resolution Bruker NMR systems (a 500 MHz narrow-bore and a 300 MHz wide-bore magnets) for ex vivo experiments on tissue extracts, cell cultures, and perfused organs. Although there is a high demand, the University of Colorado still does not have any MRS/MRI capabilities for animals; our existing imaging equipment is not sufficient to support the many needs of our investigators. UCHSC has several faculty members with extensive experience with animal MRI/MRS scanners who will be responsible for operation and maintenance of the requested PharmaScan. Specifically, having the first animal scanner at UCHSC, we will be able (a) to support all investigators of basic and translational research which is related to small animals; (b) to share imaging research resources to be used intradepartmentally and intrainstitutionally in Colorado; (c) to train both professional and technical support personnel in the science and techniques of small animal imaging; (d) to develop novel sophisticated methods in the area of molecular imaging. The requested PharmaScan will be placed in the MRS/MRI suite of the new Vivarium in Research Complex I on UCHSC's new Fitzsimons campus. This location will be ideal since animals will not have to be removed from the animal facility for MRS/MRI studies. The Departments of Anesthesiology, Pharmacology and the Cancer Center have committed sufficient financial resources for setting up, running and maintaining the instrument. This is a much needed instrumentation and will provide an important regional facility for in vivo research in Colorado and the surrounding Rocky Mountain region.

描述（由申请人提供）： 在此提案中，我们要求为Bruker 4.7/16 Pharmascan Rodent MRI/夫人Scanner提供资金。在过去的十年中，MRI和MRS（磁共振成像和光谱法）在药物发现，基本临床前研究以及假设驱动的生物医学研究方面表现出了巨大的希望。这些快速发展的技术的优点是它们的非侵入性质以及可以监测的解剖学，生理和生化参数的丰富性。在过去的一年中，麻醉学部已经建立了一个生物医学MRS实验室，该实验室具有两个高分辨率的Bruker NMR系统（一个500 MHz狭窄的孔和300 MHz宽孔磁铁），用于在组织，细胞培养物和细胞培养物和灌注器官方面进行过体实验。尽管需求很高，但科罗拉多大学仍然没有任何动物的MRS/MRI能力。我们现有的成像设备不足以满足调查人员的许多需求。 UCHSC拥有几位在动物MRI/MRS扫描仪中拥有丰富经验的教职员工，他们将负责对要求的Pharmascan的操作和维护。具体来说，拥有UCHSC的第一个动物扫描仪，我们将能够（a）支持所有与小动物有关的基本和转化研究的研究者； （b）共享科罗拉多州的内部和机构内部使用的成像研究资源； （c）在小动物成像的科学和技术中培训专业和技术支持人员； （d）在分子成像区域开发新的复杂方法。所请求的Pharmascan将被放置在UCHSC New Fitzsimons校园的研究大楼新Vivarium的MRS/MRI套件中。该位置将是理想的选择，因为不必从动物设施中删除动物进行MRS/MRI研究。麻醉，药理学和癌症中心的部门已投入足够的财务资源来建立，运行和维护该工具。这是一种急需的仪器，将为科罗拉多州和周围落基山地区的体内研究提供重要的区域设施。

项目成果

Magnetic resonance spectroscopy of living tissues.

活体组织的磁共振波谱。

• DOI: 10.1007/978-1-60327-811-9_22
• 发表时间: 2009
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Serkova,NatalieJ;Hasebroock,KendraM;Kraft,SusanL
• 通讯作者: Kraft,SusanL