FUNCTIONAL IMAGING OF STRIATE CORTEX

纹状皮层的功能成像

• 批准号: 2838278
• 负责人: GARY G BLASDEL
• 金额: $ 31.81万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2838278
• 关键词: Macaca; Saimiri; brain imaging /visualization /scanning; brain mapping; cats; cerebral dominance; electrophysiology; histology; microelectrodes; neural information processing; neuroanatomy; single cell analysis; visual cortex; visual fields

The video imaging technique we developed 11 years ago (Blasdel and Salama, 1986) has provided numerous insights into the functional organization of primate visual cortex. Not only has it provided the first (and still the only) maps of orientation preference in visual areas 1 and 2, it has also provided the only maps of different response patterns (e.g., orientation, ocular dominance, retinopy) from the same cortical location: maps on the basis of which previously unknown local interactions were inferred (Blasdel, 1992; Obermayer and Blasdel, 1993). Funds are therefore requested to continue these efforts in three groups of experiments that should expand our understanding further. In one group of experiments we plan to compare differential images, obtained simultaneously and without dye from the same cortical regions, with two or more different wavelengths of light. Of particular interest will be the relative independence of changes monitored at different wavelengths, and ways in which these changes in reflectance might be combined to infer additional information (e.g., about depth), or to achieve superior signal to noise ratios. In another set of experiments, we plan to continue our analysis of ways in which optically imaged patterns reflect the receptive field properties of upper layer neurons. In a final group of experiments, we plan to compare differential images of ocular dominance, position, and orientation so that new information about local interactions (e.g., between ocular dominance and position, or between position and orientation, etc.) can be inferred. Collectively, these experiments are designed to increase our understanding of visual information processing in the visual cortex of primates.

我们11年前开发的视频成像技术（Blasdel和 Salama，1986）提供了许多关于功能性的见解 灵长类视觉皮层的组织。 它不仅提供了 第一个（也是唯一的）视觉方向偏好图 区域1和区域2，还提供了唯一的不同响应的地图 相同的模式（例如，方向、眼优势、视网膜） 皮质位置：根据先前未知的局部进行映射 推断出相互作用（Blasdel，1992；Obermayer 和 Blasdel，1993）。 因此，需要资金来继续分三组进行这些努力 应该进一步扩大我们的理解的实验。 合而为一 我们计划比较一组实验，获得的差异图像 同时并且没有来自相同皮质区域的染料，有两个 或更多不同波长的光。 特别感兴趣的是 在不同波长下监测的变化的相对独立性， 以及将这些反射率变化结合起来的方式 推断附加信息（例如，关于深度），或获得更好的结果 信噪比。 在另一组实验中，我们计划 继续我们分析光学成像图案的反射方式 上层神经元的感受野特性。 在最后一组 在实验中，我们计划比较眼部的差异图像 优势、位置和方向，以便获得有关本地的新信息 相互作用（例如，眼睛优势和位置之间，或之间 位置和方向等）可以推断。 总的来说，这些 实验旨在增加我们对视觉的理解 灵长类动物视觉皮层的信息处理。