DEVELOPMENTAL ORGANIZATIONS IN NEONATAL CORTEX

新生儿皮质的发育组织

基本信息

批准号：
2444376
负责人：
GARY G BLASDEL
金额：
$ 13.11万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-07-01 至 1999-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2444376
关键词：
Macaca behavioral /social science research tag brain circulation brain imaging /visualization /scanning brain mapping central neural pathway /tract developmental neurobiology eye refraction disorder infant animal intercellular connection visual cortex visual perception

项目摘要

Previous work has shown that optical imaging can be used to visualize maps of ocular dominance, orientation, and retinotopic position in the striate cortex of living animals. More recently we have shown that these techniques can also be applied to infant macaque monkeys and that the resulting maps suggest several developmental events that had not been suspected previously, namely: 1) that striate cortex in neonatal animals may grow anisotropically, expanding perpendicular to the ocular dominance columns, 2) that this differential growth may account for anisotropic magnifications seen in adults, and 3) that patterns of orientation selectivity and ocular dominance may drift in relation to each other as young animals mature. In order to evaluate these possibilities we propose further experiments to monitor the development of ocular dominance, orientation selectivity and cortical magnification in identified regions of striate cortex between birth and 14 weeks of age. By following the development of these patterns in the same cortical regions these experiments should avoid problems with individual variation and thereby provide clearer insights into the development of functional organization in the visual cortex of neonatal primates. Funds are therefore requested to supplement ongoing studies of adult striate cortex, so that attempts can be made to extend optical imaging techniques to longitudinal studies in infants.

先前的工作表明光学成像可用于可视化眼优势、方向和视网膜位置的图活体动物的纹状皮层。最近我们已经证明这些该技术也可以应用于幼年猕猴，并且由此产生的地图表明了一些尚未被记录的发展事件先前怀疑，即：1）新生动物的纹状皮层可能各向异性生长，垂直于眼睛扩展优势列，2）这种差异增长可能解释成人中看到的各向异性放大率，3）方向选择性和眼优势可能会发生漂移彼此就像年幼的动物成熟一样。为了评价这些我们提出进一步的实验来监测发展的可能性眼优势、方向选择性和皮质放大率出生至 14 周期间纹状皮层的确定区域年龄。通过跟踪这些模式在同一皮质中的发展这些实验应避免个人的问题变化，从而为发展提供更清晰的见解新生灵长类动物视觉皮层的功能组织。因此，需要资金来补充正在进行的成人研究纹状皮层，以便可以尝试扩展光学成像婴儿纵向研究的技术。