DEVELOPMENTAL ORGANIZATIONS IN NEONATAL CORTEX

新生儿皮质的发育组织

基本信息

批准号：
2444376
负责人：
GARY G BLASDEL
金额：
$ 13.11万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-07-01 至 1999-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2444376
关键词：
Macaca behavioral /social science research tag brain circulation brain imaging /visualization /scanning brain mapping central neural pathway /tract developmental neurobiology eye refraction disorder infant animal intercellular connection visual cortex visual perception

项目摘要

Previous work has shown that optical imaging can be used to visualize maps of ocular dominance, orientation, and retinotopic position in the striate cortex of living animals. More recently we have shown that these techniques can also be applied to infant macaque monkeys and that the resulting maps suggest several developmental events that had not been suspected previously, namely: 1) that striate cortex in neonatal animals may grow anisotropically, expanding perpendicular to the ocular dominance columns, 2) that this differential growth may account for anisotropic magnifications seen in adults, and 3) that patterns of orientation selectivity and ocular dominance may drift in relation to each other as young animals mature. In order to evaluate these possibilities we propose further experiments to monitor the development of ocular dominance, orientation selectivity and cortical magnification in identified regions of striate cortex between birth and 14 weeks of age. By following the development of these patterns in the same cortical regions these experiments should avoid problems with individual variation and thereby provide clearer insights into the development of functional organization in the visual cortex of neonatal primates. Funds are therefore requested to supplement ongoing studies of adult striate cortex, so that attempts can be made to extend optical imaging techniques to longitudinal studies in infants.

以前的工作表明，光学成像可用于可视化眼部优势，方向和视网膜位置的地图活动物的条纹皮质。最近，我们证明了这些技术也可以应用于婴儿猕猴，由此产生的地图表明了几个没有发生的发展事件以前怀疑，即：1）在新生动物中划分皮质可能会偶然生长，垂直于眼部扩展优势列，2）这种差异增长可能解释在成年人中看到的各向异性宏伟，3）方向选择性和眼部优势可能相对于彼此随着年轻动物的成熟。为了评估这些我们建议进一步监测开发的可能性眼部优势，定向选择性和皮质放大倍率在出生与14周之间确定的条纹皮质区域年龄。通过在同一皮质中遵循这些模式的发展区域这些实验应避免个人问题变化，从而为发展提供了更清晰的见解新生儿灵长类动物的视觉皮层中的功能组织。因此，要求资金补充成人正在进行的研究条纹皮层，以便可以尝试扩展光学成像婴儿纵向研究的技术。