DEVELOPMENTAL ORGANIZATION IN NEONATAL CORTEX

新生儿皮质的发育组织

• 批准号: 6277821
• 负责人: GARY G BLASDEL
• 金额: $ 7.56万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277821
• 关键词: Mammalia; Primates; growth /development; nervous system

Previous work has shown that optical imaging can be used to visualize maps of ocular dominance, orientation, and retinotopy in macaque striate cortex and to follow their development in young animals. In addition to verifying the existence of many adult organizations in infants, these studies also revealed several unexpected developmental reorganizations, namely 1) that neonatal V1 grows anisotropically, perpendicular to ocular dominance columns, 2) that the resulting distortions may generate anisotropic magnification factors in adults, and 3) that ocular dominance and orientation patterns may drift in relation to each other (and anatomical landmarks), as the cortex expands. In order to investigate these possibilities further, we proposed longitudinal experiments in single animals, to obtain images of ocular dominance, orientation, and position (magnification) repeatedly from the same regions. Fully analyzed data from our first experimental animals now show that cortex expands anisotropically, perpendicular to OD columns, during development (as expected), and several observations that were not expected though they are consistent with other findings. These are 1) that neonatal V1 undergoes shearing (twisting) during development, and 2) that new features (e.g., OD bifurcations) may be added in some regions as the cortical surface expands. Since the approach clearly works and the findings are clearly relevant to developmental pathologies in humans (e.g., amblyopia, stereoblindness, etc.), funds are requested to continue these efforts in more animals, to explore these changes at more eccentricities and in greater detail.

先前的工作表明光学成像可用于 可视化眼优势、方向和视网膜定位图 猕猴纹状皮层并跟踪其幼年发育 动物。 除了验证许多成年人的存在之外 婴儿组织中，这些研究还揭示了一些 意外的发育重组，即 1) 新生儿 V1 各向异性生长，垂直于眼优势柱，2) 由此产生的扭曲可能会产生各向异性放大 成人的因素，以及 3) 眼的优势和方向 模式可能会相对于彼此发生漂移（并且解剖学上 地标），随着皮层的扩张。 为了调查这些 进一步的可能性，我们提出了单次纵向实验 动物，以获得眼部优势、方向和 从相同区域重复定位（放大）。 完全 我们第一批实验动物的分析数据现在表明，皮质 各向异性膨胀，垂直于 OD 柱，在 发展（如预期），以及一些未实现的观察结果 尽管它们与其他发现一致，但仍符合预期。 这些是 1) 新生儿 V1 在发育过程中经历剪切（扭曲），并且 2）新特征（例如，OD分叉）可能会添加到某些 皮质表面扩张时的区域。 由于方法明确 工作和研究结果显然与发展相关 人类病理（例如弱视、立体盲等）、资金 要求在更多动物中继续这些努力，探索 这些变化更加古怪、更加详细。