FUNCTIONAL IMAGING OF STRIATE CORTEX

纹状皮层的功能成像

• 批准号: 6277822
• 负责人: GARY G BLASDEL
• 金额: $ 7.56万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277822
• 关键词: Mammalia; Primates; nervous system

Results obtained during the previous two grant periods have revealed new insights into the organization of primate visual cortex, most of which appear reasonable (in that they are consistent with previous observations), but few of which were known to be organized exactly as they have now been shown to be through optical imaging techniques. In addition to revealing the first actual maps of orientation selectivity, ocular dominance, and most recently position, results from this lab have additionally shown interactions among them that could facilitate perception. Funds are therefore requested to continue these efforts, using optical imaging to explore new functional architectures, or find them so they can be explored in greater detail in micro-electrodes and tracer injections at strategic locations. In one group of experiments, maps of retinotopic space will be obtained at different resolutions to find the minimum patterns where patterns can still be seen (Blasdel and Campbell, 1997), so that micro-electrodes can be used to explore the same areas to determine the extent to which this positional variance arises from cortical receptive field size or scatter, and whether the ration of contributions from these two varies at different locations (e.g., at the centers or edges of linear zones, singularities, blobs, etc.). Due to the recent publication of optical imaging studies based on shorter (600 nm) wavelength light, we also plan to continue comparing maps obtained at different (e.g., 610 and 720) wavelengths to determine the possible advantages of each as well as to explore possible benefits from obtaining images with both wavelengths - separately but simultaneously - used in combination. These experiments are designed to increase or understanding of visual information processing and associated structure-function relationships in the upper layers of primate visual cortex.

前两个资助期间取得的成果 揭示了对灵长类视觉皮层组织的新见解， 其中大部分看起来合理（因为它们与 之前的观察），但其中很少有人知道是有组织的 正如现在通过光学成像所显示的那样 技术。 除了揭晓第一张实际地图外 方向选择性、眼优势和最近的位置， 该实验室的结果还显示了它们之间的相互作用 这可以促进感知。 因此需要资金 继续这些努力，利用光学成像探索新的 功能架构，或者找到它们，以便可以在其中进行探索 战略性微电极和示踪剂注射的更多细节 地点。 在一组实验中，视网膜专题空间图 将在不同的分辨率下获得找到最小的模式 仍然可以看到模式（Blasdel 和 Campbell，1997），因此 微电极可用于探索相同区域以确定 这种位置差异由皮质引起的程度 感受野大小或分散度，以及是否 这两者的贡献在不同地点有所不同（例如，在 线性区域、奇点、斑点等的中心或边缘）。到期的 最近发表的基于较短的光学成像研究 （600 nm）波长光，我们还计划继续比较图 在不同（例如 610 和 720）波长下获得以确定 每个可能的优点以及探索可能的好处 从获得两个波长的图像 - 分开但 同时 - 组合使用。 这些实验是设计 增加或理解视觉信息处理和 上层相关的结构-功能关系 灵长类视觉皮层。