Arterial stiffness, blood pressure and cognition

动脉僵硬度、血压和认知

• 批准号: 6958156
• 负责人: MERRILL F ELIAS
• 金额: $ 68.06万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6958156
• 关键词: age difference; aorta; behavioral /social science research tag; blood pressure; brain circulation; cardiovascular disorder diagnosis; cardiovascular disorder risk; carotid artery; clinical research; cognition disorders; diagnosis design /evaluation; disease /disorder proneness /risk; heart contraction; human subject; hypertension; longitudinal human study; mental health epidemiology; neuropsychological tests; prognosis; psychological aspect of aging; psychometrics; pulse pressure wave; questionnaires; vascular resistance

Our overall study hypothesis is that arterial stiffness plays an increasingly important role in the relationship between high blood pressure (BP) and lowered cognitive performance with advancing age and is an independent risk factor for lowered cognitive performance. Aortic pulse wave velocity (aPWV) and related measures (Augmentation Index) are reliable and valid indices of arterial stiffness. We propose to call back 900 individuals participating in longitudinal studies of brachial BP and cognitive performance for a new study relating arterial stiffness to cognitive performance. We will also introduce new central aortic and carotid BP measures and relate them to cognitive functioning. All of the current investigations relating BP to cognitive performance have employed the traditional pressure-cuff method of assessing BP at the brachial artery (a peripheral BP assessment). We will introduce applanation tonometry technology. This will allow us to examine relations between aPWV and cognitive functioning, as well as "closer to the brain" arterial (aortic and carotid) BP estimates and cognitive functioning. Among our major hypotheses are: (1) aPWV will be an independent predictor of cognitive performance; (2) aPWV will exhibit a greater magnitude of association with cognitive performance for older than for younger persons; (3) magnitude of associations between the site-specific BP variables and cognitive functioning will be ordered as follows, highest to lowest, carotid BP> aortic BP> brachial BP; (4) greater differences among these pressures will be observed for systolic than diastolic pressure and for younger than older adults. The hypothesized relations will hold despite statistical adjustment for variables which confound relations between BP and cognitive performance and may confound relations between aPWV and cognitive performance. As an ancillary benefit of these new studies, we will continue a 29-year longitudinal study relating brachial artery BP to cognitive performance, thus allowing us to examine both linear and non-linear relations between brachial BP and changes in performance with age.

我们的整体研究假设是，动脉僵硬在高血压（BP）之间的关系中起着越来越重要的作用，并且随着年龄的增长，认知表现降低，并且是降低认知能力的独立危险因素。主动脉脉冲波速度（APWV）和相关措施（增强指数）是可靠且有效的动脉刚度指标。我们建议回电900名参加臂BP纵向研究和认知表现的个人，以进行一项新的研究，将动脉僵硬与认知性能有关。我们还将引入新的中央主动脉和颈动脉BP测量，并将其与认知功能联系起来。目前的所有BP与认知性能有关的研究都采用了传统的压力裁缝方法来评估臂动脉的BP（外围BP评估）。我们将介绍应用Tonometry技术。这将使我们能够检查APWV和认知功能之间的关系，以及“更靠近大脑”动脉（主动脉和颈动脉）BP估计和认知功能。我们的主要假设之一是：（1）APWV将是认知表现的独立预测指标； （2）APWV将比老年人比老年人表现出更大的与认知表现的关联； （3）位点特异性BP变量与认知功能之间的关联幅度将如下排序，最高至最低，颈动脉BP>主动脉BP>臂bp>臂BP； （4）对于收缩压，这些压力的差异比舒张压和年轻人年轻。尽管对变量进行了统计调整，这些关系仍将存在，这些变量将BP与认知表现之间的关系混淆，并可能混淆APWV与认知绩效之间的关系。作为这些新研究的辅助优势，我们将继续进行29年的纵向研究，将臂动脉BP与认知性能有关，从而使我们能够检查臂BP与年龄变化之间的线性和非线性关系。