Arterial stiffness, blood pressure and cognition

动脉僵硬度、血压和认知

• 批准号: 6958156
• 负责人: MERRILL F ELIAS
• 金额: $ 68.06万
• 依托单位: UNIVERSITY OF MAINE ORONO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6958156
• 关键词: age difference; aorta; behavioral /social science research tag; blood pressure; brain circulation; cardiovascular disorder diagnosis; cardiovascular disorder risk; carotid artery; clinical research; cognition disorders; diagnosis design /evaluation; disease /disorder proneness /risk; heart contraction; human subject; hypertension; longitudinal human study; mental health epidemiology; neuropsychological tests; prognosis; psychological aspect of aging; psychometrics; pulse pressure wave; questionnaires; vascular resistance

Our overall study hypothesis is that arterial stiffness plays an increasingly important role in the relationship between high blood pressure (BP) and lowered cognitive performance with advancing age and is an independent risk factor for lowered cognitive performance. Aortic pulse wave velocity (aPWV) and related measures (Augmentation Index) are reliable and valid indices of arterial stiffness. We propose to call back 900 individuals participating in longitudinal studies of brachial BP and cognitive performance for a new study relating arterial stiffness to cognitive performance. We will also introduce new central aortic and carotid BP measures and relate them to cognitive functioning. All of the current investigations relating BP to cognitive performance have employed the traditional pressure-cuff method of assessing BP at the brachial artery (a peripheral BP assessment). We will introduce applanation tonometry technology. This will allow us to examine relations between aPWV and cognitive functioning, as well as "closer to the brain" arterial (aortic and carotid) BP estimates and cognitive functioning. Among our major hypotheses are: (1) aPWV will be an independent predictor of cognitive performance; (2) aPWV will exhibit a greater magnitude of association with cognitive performance for older than for younger persons; (3) magnitude of associations between the site-specific BP variables and cognitive functioning will be ordered as follows, highest to lowest, carotid BP> aortic BP> brachial BP; (4) greater differences among these pressures will be observed for systolic than diastolic pressure and for younger than older adults. The hypothesized relations will hold despite statistical adjustment for variables which confound relations between BP and cognitive performance and may confound relations between aPWV and cognitive performance. As an ancillary benefit of these new studies, we will continue a 29-year longitudinal study relating brachial artery BP to cognitive performance, thus allowing us to examine both linear and non-linear relations between brachial BP and changes in performance with age.

我们的总体研究假设是，随着年龄的增长，动脉僵硬度在高血压（BP）和认知能力下降之间的关系中发挥着越来越重要的作用，并且是认知能力下降的独立危险因素。主动脉脉搏波速度（aPWV）和相关测量（增强指数）是可靠且有效的动脉僵硬度指标。我们建议召回 900 名参与肱动脉血压和认知能力纵向研究的个体，以进行一项将动脉僵硬度与认知能力相关的新研究。我们还将引入新的中央主动脉和颈动脉血压测量并将其与认知功能联系起来。目前所有有关血压与认知能力的研究均采用传统的压力袖带方法来评估肱动脉血压（外周血压评估）。我们将介绍压平眼压测量技术。这将使我们能够检查 aPWV 和认知功能之间的关系，以及“更接近大脑”的动脉（主动脉和颈动脉）血压估计和认知功能。我们的主要假设包括：（1）aPWV 将成为认知表现的独立预测因子； (2) 与年轻人相比，老年人的 aPWV 与认知能力的相关性更大； (3) 特定部位血压变量与认知功能之间的关联程度按以下顺序排列，从高到低，颈动脉血压>主动脉血压>肱动脉血压； (4) 在这些压力中，收缩压的差异大于舒张压，年轻人的差异大于老年人的差异。尽管对混淆血压和认知表现之间关系的变量进行统计调整，并且可能混淆 aPWV 和认知表现之间的关系，但假设的关系仍然成立。作为这些新研究的附带好处，我们将继续进行一项为期 29 年的纵向研究，将肱动脉血压与认知能力联系起来，从而使我们能够检查肱动脉血压与认知能力随年龄变化之间的线性和非线性关系。