Neuropharmacology of Cocaine in Nonhuman Primates

可卡因在非人类灵长类动物中的神经药理学

• 批准号: 7099914
• 负责人: LEONARD L HOWELL
• 金额: $ 12.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7099914
• 关键词: Macaca mulatta; Saimiri; amines; behavior test; brain imaging /visualization /scanning; central nervous system stimulants; cocaine; dopamine; drug abuse chemotherapy; injection /infusion; microdialysis; neurochemistry; neuropharmacology; neuropsychology; operant conditionings; positron emission tomography; psychological reinforcement; reinforcer; self medication; serotonin; stereotaxic techniques; substance abuse related behavior; technology /technique development

DESCRIPTION (provided by applicant): The career development plan described in this competing renewal application will allow the applicant to continue the development and expansion of his research career into new areas of investigation that complement current areas of expertise. The applicant has extensive training and experience in behavioral neuropharmacology and substance abuse with primary expertise in the neuropharmacology of CMS stimulants. During the previous funding period, the applicant developed in vivo microdialysis techniques in conscious monkeys trained to self-administer cocaine and related stimulants in order to determine neurochemical changes associated with the behavioral and reinforcing properties of abused stimulants. In addition, the development of positron emission tomography (PET) imaging techniques in conscious monkeys expanded further the applicant's ability to characterize and quantify the CMS effects of abused stimulants. More recent efforts have focused on the development of functional magnetic resonance imaging (fMRI) in conscious monkeys to document with high temporal and spatial resolution drug-induced changes in CMS activity. A major focus of the research plan will involve the pharmacological manipulation of monoamine and glutamate systems to assess potential changes in sensitivity to the CNS effects of cocaine. The studies proposed will provide an innovative preclinical model to identify useful pharmacotherapies for stimulant abuse. In addition to research activities, the applicant will commit effort to educational activities related to biomedical research and substance abuse. The host institution, Emory University, has a well-established program related to neuroscience and substance abuse research that is ideally suited to the career development plan. The University will provide the necessary resources and adequate time to ensure the development of the applicant as a productive, independent research scientist. The long-term commitment and support provided by continuation of the Independent Scientist Award will provide the opportunity to develop and integrate new skills and expertise into a unique multidisciplinary research program in substance abuse.

描述（由申请人提供）：本次竞争更新申请中描述的职业发展计划将使申请人能够继续发展和扩展其研究生涯，进入新的研究领域，以补充当前的专业领域。申请人在行为神经药理学和药物滥用方面拥有广泛的培训和经验，在 CMS 兴奋剂的神经药理学方面拥有主要专业知识。在上一个资助期间，申请人在经过训练的有意识的猴子中开发了体内微透析技术，这些猴子经过训练可以自我施用可卡因和相关兴奋剂，以确定与滥用兴奋剂的行为和强化特性相关的神经化学变化。此外，在有意识的猴子中正电子发射断层扫描（PET）成像技术的发展进一步扩展了申请人表征和量化滥用兴奋剂的CMS效应的能力。最近的工作重点是在有意识的猴子中开发功能性磁共振成像 (fMRI)，以高时间和空间分辨率记录药物引起的 CMS 活性变化。该研究计划的一个主要重点将涉及单胺和谷氨酸系统的药理学操作，以评估对可卡因中枢神经系统影响的敏感性的潜在变化。拟议的研究将提供一种创新的临床前模型，以确定针对兴奋剂滥用的有用药物疗法。除了研究活动外，申请人还将致力于与生物医学研究和药物滥用相关的教育活动。主办机构埃默里大学拥有与神经科学和药物滥用研究相关的完善项目，非常适合职业发展计划。大学将提供必要的资源和充足的时间，以确保申请人发展成为一名富有成效的、独立的研究科学家。独立科学家奖的延续所提供的长期承诺和支持将为开发新技能和专业知识并将其整合到药物滥用方面的独特多学科研究项目中提供机会。