Neuropharmacology of Cocaine in Nonhuman Primates

可卡因在非人类灵长类动物中的神经药理学

• 批准号: 7099914
• 负责人: LEONARD L HOWELL
• 金额: $ 12.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7099914
• 关键词: Macaca mulatta; Saimiri; amines; behavior test; brain imaging /visualization /scanning; central nervous system stimulants; cocaine; dopamine; drug abuse chemotherapy; injection /infusion; microdialysis; neurochemistry; neuropharmacology; neuropsychology; operant conditionings; positron emission tomography; psychological reinforcement; reinforcer; self medication; serotonin; stereotaxic techniques; substance abuse related behavior; technology /technique development

DESCRIPTION (provided by applicant): The career development plan described in this competing renewal application will allow the applicant to continue the development and expansion of his research career into new areas of investigation that complement current areas of expertise. The applicant has extensive training and experience in behavioral neuropharmacology and substance abuse with primary expertise in the neuropharmacology of CMS stimulants. During the previous funding period, the applicant developed in vivo microdialysis techniques in conscious monkeys trained to self-administer cocaine and related stimulants in order to determine neurochemical changes associated with the behavioral and reinforcing properties of abused stimulants. In addition, the development of positron emission tomography (PET) imaging techniques in conscious monkeys expanded further the applicant's ability to characterize and quantify the CMS effects of abused stimulants. More recent efforts have focused on the development of functional magnetic resonance imaging (fMRI) in conscious monkeys to document with high temporal and spatial resolution drug-induced changes in CMS activity. A major focus of the research plan will involve the pharmacological manipulation of monoamine and glutamate systems to assess potential changes in sensitivity to the CNS effects of cocaine. The studies proposed will provide an innovative preclinical model to identify useful pharmacotherapies for stimulant abuse. In addition to research activities, the applicant will commit effort to educational activities related to biomedical research and substance abuse. The host institution, Emory University, has a well-established program related to neuroscience and substance abuse research that is ideally suited to the career development plan. The University will provide the necessary resources and adequate time to ensure the development of the applicant as a productive, independent research scientist. The long-term commitment and support provided by continuation of the Independent Scientist Award will provide the opportunity to develop and integrate new skills and expertise into a unique multidisciplinary research program in substance abuse.

描述（由申请人提供）：在此竞争性续签申请中描述的职业发展计划将使申请人能够继续发展和扩展其研究生涯，以补充当前专业知识领域的新调查领域。申请人在CMS兴奋剂的神经药理方面具有行为神经药理和药物滥用的广泛培训和经验。在上一个融资期间，申请人在有意识的猴子中开发了体内微透析技术，该技术接受了自我管理的可卡因和相关刺激剂，以确定与滥用刺激剂的行为和增强特性相关的神经化学变化。此外，有意识猴子中正电子发射断层扫描（PET）成像技术的发展进一步扩展了申请人表征和量化滥用刺激剂的CMS效应的能力。最近的努力集中在有意识的猴子中功能磁共振成像（fMRI）的发展，以记录具有高时空和空间分辨率药物诱导的CMS活性变化的记录。研究计划的主要重点将涉及单胺和谷氨酸系统的药理操作，以评估对可卡因中枢神经系统影响的敏感性的潜在变化。提出的研究将提供一个创新的临床前模型，以确定刺激滥用的有用药物治疗。除了研究活动外，申请人还将努力致力于与生物医学研究和滥用药物有关的教育活动。主办机构埃默里大学（Emory University）拥有与神经科学和药物滥用研究有关的完善计划，非常适合职业发展计划。该大学将提供必要的资源和足够的时间，以确保申请人作为一名富有成效的独立研究科学家的发展。独立科学家奖的延续提供的长期承诺和支持将为开发和整合新技能和专业知识与药物滥用方面的独特多学科研究计划。