NEUROPHARMACOLOGY OF COCAINE

可卡因的神经药理学

• 批准号: 6230872
• 负责人: LEONARD L HOWELL
• 金额: $ 7.65万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6230872
• 关键词: Macaca mulatta; Saimiri; amines; behavior test; brain imaging /visualization /scanning; central nervous system stimulants; cocaine; dopamine; drug abuse chemotherapy; injection /infusion; microdialysis; neurochemistry; neuropharmacology; neuropsychology; operant conditionings; positron emission tomography; psychological reinforcement; reinforcer; self medication; serotonin; stereotaxic techniques; substance abuse related behavior; technology /technique development

DESCRIPTION: (Applicant's Abstract) The career development plan described in the present proposal will allow the applicant to develop and expand his research career into new areas of investigation that complement current areas of expertise. The applicant has extensive training and experience in behavioral neuropharmacology and substance abuse with primary expertise in the neuropharmacology of CNS stimulants. The proposed development of in vivo microdialysis techniques in conscious monkeys trained to self-administer cocaine and related stimulants will allow for the determination of neurochemical changes associated with the behavioral and reinforcing properties of abused stimulants. The capacity to study neurochemistry directly during ongoing behavioral experiments will be a major advancement in the research career of the applicant. In addition, the development of positron emission tomography (PET) imaging techniques in conscious monkeys will expand further the applicant's ability to characterize and quantify the CNS effects of abused stimulants. A major focus of the research plan will involve the pharmacological manipulation of monoamine systems to assess potential changes in sensitivity to the CNS effects of cocaine. The studies proposed will provide an innovative pre-clinical model to identify useful pharmacotherapies for stimulant abuse. In addition to research activities, the applicant will commit effort to educational activities related to biomedical research and substance abuse. The host institution, Emory University, has a well-established program related to neuroscience and substance abuse research that is ideally suited to the career development plan. The University will provide the necessary resources and adequate time to ensure the development of the applicant as a productive, independent research scientist. The long-term commitment and support provided by an Independent Scientist Award will provide the opportunity to develop and integrate new skills and expertise into a unique multidisciplinary research program in substance abuse.

描述：（申请人的摘要） 本提案中描述的职业发展计划将允许 申请人将其研究生涯发展和扩展到新领域 调查与当前专业知识领域相辅相成。申请人有 广泛的培训和行为神经药理和物质的经验 滥用CNS兴奋剂神经药理的主要专业知识。这 意识猴子中的体内微透析技术的拟议开发 经过自我管理可卡因和相关兴奋剂的训练将允许 确定与行为和行为相关的神经化学变化 滥用刺激物的增强特性。学习能力 在进行的行为实验期间，神经化学直接将是主要的 申请人研究职业的进步。另外， 推广发射断层扫描（PET）成像技术的开发 有意识的猴子将进一步扩大申请人的表征能力 并量化滥用兴奋剂的中枢神经系统效应。主要重点 研究计划将涉及单胺的药理操作 评估对中枢神经系统影响的潜在变化的系统 可卡因。提出的研究将提供创新的临床前模型 确定有用的药物疗法来刺激刺激。除了研究 活动，申请人将努力与教育活动相关 生物医学研究和滥用药物。主机机构，埃默里 大学有一个与神经科学和 非常适合职业发展计划的药物滥用研究。 大学将提供必要的资源和足够的时间来确保 申请人作为一项富有成效的独立研究的发展 科学家。独立的长期承诺和支持 科学家奖将为开发和整合新的机会 技能和专业知识成为独特的多学科研究计划 药物滥用。