DOPPLER ULTRASOUND VENOUS EMBOLI MONITOR

多普勒超声静脉栓塞监测仪

• 批准号: 2901271
• 负责人: Mark A Moehring
• 金额: $ 35.2万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2901271
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; blood circulation; cardiovascular disorder diagnosis; clinical research; diagnosis design /evaluation; disease /disorder proneness /risk; human subject; patient monitoring device; phantom model; pulmonary artery; pulmonary circulation obstruction; ultrasound blood flow measurement; veins; venous thrombosis

Pulmonary embolism (PE) caused by emboli (blood clots) from deep venus thrombosis (DVT) is a major cause of death in otherwise healthy adults, many occurring without clinical warning and earning PE the reputation as "silent killer". Great need exists in clinical practice for an unattended device to detect venous embolization. The demonstrated capability of Doppler ultrasound to detect particularly microemboli will be the basis for constructing a new tool to accurately and cost effectively identify individuals at risk of PE which will: detect microemboli in the venous circulation, guide therapeutic measures, and determine their effectiveness. In Phase I a dual-gate Doppler was designed and constructed, and then was used to demonstrate a 25% prevalence rate of microemboli in a population of 20 patients with confirmed DVT. 80% of patients presenting microemboli had been on heparin therapy for a day or less. In Phase II, a novel device with enhancements for easy location of the pulmonary artery or femoral vein will be constructed and used to determine prevalence of microemboli in a series of patients presenting with high risk for DVT. Phase II results will be used to design a Phase III devise for the large anticipated commercial market. Proposed commercial applications: The project will lead to a unique commercial instrument with a large market potential to monitor for the presence of formed element emboli in the venous circulation from deep venous thrombosis, a major cause of pulmonary embolism (PE). Once detected, anticoagulant therapy can be administered by physicians to prevent or reduce the risk PE. Other markets and applications include a monitor for decompression bubble in divers, pilots and astronauts, embolism in neurosurgery, orthopedic surgery, and fractures of extremities.

由深静脉血栓（血凝块）引起的肺栓塞 (PE) 血栓 (DVT) 是其他健康成年人死亡的主要原因， 许多在没有临床预警的情况下发生，并为PE赢得了“ “沉默的杀手”。临床实践中非常需要无人值守的 检测静脉栓塞的装置。 多普勒超声已证明能够检测特别是 微栓子将成为构建新工具的基础，以准确地 并经济有效地识别有 PE 风险的个人，这将： 静脉循环中的微栓子，指导治疗措施，以及 确定它们的有效性。 在第一阶段，设计并建造了双门多普勒仪，然后 用于证明人群中微栓子的患病率为 25% 20 名确诊 DVT 的患者。 80% 的患者出现微栓塞 接受肝素治疗一天或更短时间。 在第二阶段，一种新颖的设备具有增强功能，可以轻松定位 将构建肺动脉或股静脉并用于确定 一系列患有高风险的患者中微栓子的患病率 DVT 风险。 第二阶段的结果将用于设计大型的第三阶段设备 预期的商业市场。 拟议的商业应用： 该项目将带来一种独特的商业工具，具有巨大的 监测有形成分栓塞存在的市场潜力 深静脉血栓形成导致的静脉循环障碍，这是导致深静脉血栓形成的主要原因 肺栓塞（PE）。一旦发现，可以进行抗凝治疗 由医生管理以预防或降低 PE 风险。其他市场 应用包括潜水员减压气泡监视器， 飞行员和宇航员、神经外科、骨科手术中的栓塞，以及 四肢骨折。