HARMONIC DOPPLER ULTRASOUND EMBOLUS CHARACTERIZATION

谐波多普勒超声栓塞表征

• 批准号: 6211168
• 负责人: Mark A Moehring
• 金额: $ 9.95万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6211168
• 关键词: air embolism; bioimaging /biomedical imaging; biomedical equipment development; embolism; phantom model; thromboembolism; ultrasound blood flow measurement

Recent Doppler ultrasound technological advances have demonstrated the unique capability to detect microemboli in the arterial and venous circulation. Microemboli have been implicated as the source or prelude of stroke and associated neurologic deficit. An unknown that would help determine the underlying pathology and the appropriate therapy is the composition of the individual microemboli. This proposal is to adapt advances in ultrasound echo processing, transducer, and harmonic detection technologies to determine microembolus composition as bubble or solid (formed element). Three areas of development are set forth: (1) adapting an existing digital Doppler platform to perform second harmonic Doppler analysis of echoes from microemboli, (2) developing a wide bandwidth ultrasound probe for normal Doppler processing at 1 MHz and second harmonic Doppler processing at 2 MHz, which have similar sensitivity patterns for each frequency, and (3) determine in vitro the best detection scheme for maximizing the ability to distinguish microbubbles from microparticles. This technology is especially important for reducing the incidence of stroke and neurologic compromise associated with various cardiovascular pathologies and surgery of the heart and of the carotid arteries. A device for discrimination of composition of microemboli represents a major commercial market potential. PROPOSED COMMERCIAL APPLICATIONS: The instrument to be developed in this project will characterize microemboli in blood flow as either gaseous or particulate, using ultrasound first and second harmonic Doppler analysis of microembolic signatures. This instrument will not require a user who is an ultrasound expert, and will target physician and technologist staff in the operating room, vascular laboratory, and emergency medicine markets. This simple to use ultrasound device will be aimed at a worldwide market.

最近的多普勒超声技术进步已经证明了在动脉和静脉循环中检测微栓塞的独特能力。微栓塞已被认为是中风的来源或前奏和相关的神经系统缺陷。一个未知的有助于确定潜在病理和适当疗法的未知是单个微栓塞的组成。该建议是为了适应超声回波处理，换能器和谐波检测技术的进步，以确定微栓塞组成为气泡或固体（形成元素）。规定了三个开发领域：（1）对现有的数字多普勒平台进行第二次谐波多普勒对微栓塞的回声进行第二次谐波多普勒分析，（2）为1 MHz和第二个谐波多普勒处理的正常多普勒处理的正常多普勒处理的正常多普勒处理的最大效果的最大效果，该计划的频率是2 MHz，（3），（3）能够区分微泡与微粒的能力。这项技术对于减少与各种心血管病理以及心脏和颈动脉手术相关的中风和神经系统妥协的发生率尤为重要。歧视微栓塞组成的设备代表了主要的商业市场潜力。拟议的商业应用：在该项目中要开发的仪器将使用超声波或第二个谐波多普勒分析微生物特征的超声分析，将血流中的微栓塞表征为气体或颗粒物。该仪器将不需要超声波专家的用户，并且将针对手术室，血管实验室和急诊医学市场的医师和技术专家。这种易于使用的超声设备将针对全球市场。