TCD Post-Resuscitation Blood Flow & Edema Monitor

TCD 复苏后血流量

• 批准号: 7066066
• 负责人: Mark A Moehring
• 金额: $ 14.97万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7066066
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood flow measurement; brain circulation; cardiopulmonary resuscitation; cerebral artery; cerebral ischemia /hypoxia; computer assisted diagnosis; computer data analysis; disease /disorder model; edema; heart arrest; human data; laser Doppler flowmetry; model design /development; myocardial ischemia /hypoxia; patient monitoring device; phantom model; stroke; swine

DESCRIPTION (provided by applicant): The aim of this project is to contribute a tool towards accomplishing improved outcomes following cardiopulmonary resuscitation (CPR). It is submitted in response to NIH program announcement PA-04-059. This proposal is to prototype an integrated Doppler ultrasound device to monitor brain blood flow and brain tissue motions in the post-resuscitation period following cardiac arrest. The technology proposed here promises high value for two considerations: (1) basic discovery of information for avoiding reperfusion injury in the post-resuscitation patient, and (2) development of a post-resuscitation monitor for commercial application, to reduce incidence of adverse outcomes currently experienced in the first thirty days following resuscitation. Power M-mode Doppler comprises the heart of this platform and is capable of monitoring four major vessels-the middle and anterior cerebral arteries, bilaterally-supplying 80% of the total blood flow to the brain, as well as perfusion related motions in the parenchyma in proximity to these vessels. The innovative core of this proposal is to combine in this platform the ability to acquire and store the following information for each of the monitored vessels in the post-resuscitation patient: blood velocity, relative blood volume flow, tissue motion dynamics (edema), and embolization. Instrument performance will be tested by phantom and then will be used to explore post-resuscitation physiology in an animal model of cardiac arrest. Our central hypothesis is that the Doppler ultrasound instrument we will construct will detect signals that correlate with known parameters indicating severity of injury in the post resuscitation period following cardiac arrest. Further, we anticipate this device will be more sensitive to the early stages of reperfusion injury that lead to acute adverse outcomes.

描述（由申请人提供）： 该项目的目的是为在心肺复苏（CPR）之后贡献一种工具，以实现改善的结果。它是根据NIH计划公告PA-04-059提交的。该提议是为了在心脏骤停后的后发出后期监测脑血流和脑组织运动的综合多普勒超声设备。此处提出的技术有望在两个考虑因素上具有很高的价值：（1）基本发现用于避免后醒来患者再灌注损伤的信息，以及（2）开发用于商业应用的后互感后监测仪，以减少复苏后最初三十天内目前经历的不良发生率。功率M模式多普勒包括该平台的心脏，能够监测四个主要血管 - 中部和前大脑动脉，双侧供应到大脑的总血液流量的80％，以及与这些容器接近实质的灌注相关运动。该提案的创新核心是在该平台中合并在后刺激后患者中获取和存储以下信息的能力：血液速度，相对血液体积流动，组织运动动力学（水肿）和栓塞。仪器的性能将由幻影测试，然后将用于探索心脏骤停动物模型中的激发后生理。我们的中心假设是，我们将构建的多普勒超声仪器将检测与已知参数相关的信号，表明心脏骤停后复苏后的损伤严重程度。此外，我们预计该设备将对再灌注损伤的早期阶段更加敏感，这会导致急性不良后果。