DOPPLER ULTRASOUND BRAIN VELOCIMETRY MONITOR

多普勒超声脑速监测仪

• 批准号: 2714701
• 负责人: Mark A Moehring
• 金额: $ 10万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714701
• 关键词: biomedical equipment development; cerebrovascular disorder diagnosis; clinical biomedical equipment; clinical research; diagnosis design /evaluation; heterodyning; human subject; intracranial hematoma; phantom model; ultrasound blood flow measurement

Intracranial hematoma from a slow venous bleed comprises a major cause of late death and disability in head trauma patients who initially appear asymptomatic. Hematoma detection is currently done by a CAT or MR scan, which is a costly and, in many hospitals, an inaccessible diagnostic modality. A need exists in clinical practice for a device to detect intracranial bleeding, that is less expensive and more widely available than CAT or MR imaging. This proposal is to develop a novel low- frequency, low PRF pulse Doppler ultrasound instrument to detect brain displacement overtime (brain velocimeter). Based on feasibility studies, the device will measure, in ten minutes, brain velocity at a series of positions between the temporal bones, the venue associated with 80% of intracranial hematomas. In Phase I, the best carrier frequency will be determined and a prototype velocimeter will be built and tested on a phantom model of intracranial hemorrhage, as well as a series of patients presenting with head trauma and referred for diagnostic CAT imaging. Phase II will include instrument redesign based on Phase I results and multi-center clinical trials. Phase II results will be used to design a Phase III device for the commercial market. PROPOSED COMMERCIAL APPLICATIONS: The instrument to be developed in this project, a brain velocimeter, will perform fast detection of very slow brain movement due to intracranial bleeding associated with head trauma. The instrument will not require an expert user and will target nurse and physician staff in the emergency medicine market. This simple to use low-tech ultrasound device will be aimed at a world wide market, especially where the current gold standard, CAT or MR imaging, is not affordable.

缓慢静脉出血的颅内血肿包括主要原因 头部创伤患者的后期死亡和残疾 无症状。血肿检测目前是由猫或MR扫描完成的 这是一家昂贵的，在许多医院中，这是一个无法访问的诊断 方式。在临床实践中存在一种需要检测的设备的需求 颅内出血，这很便宜，更广泛可用 比猫或MR成像。该建议是开发一种新颖的低 - 频率，低PRF脉冲多普勒超声仪器以检测大脑 位移加班（脑速度计）。基于可行性研究， 该设备将在十分钟内测量一系列的脑速度 颞骨之间的位置，地点与80％ 颅内血肿。在第一阶段，最好的载体频率将是 确定并在 颅内出血的幻影模型以及一系列患者 出现头部创伤并转介诊断猫成像。 第二阶段将根据第一阶段的结果重新设计仪器，并包括 多中心临床试验。第二阶段结果将用于设计 商业市场的第三阶段设备。 拟议的商业应用： 该项目中要开发的仪器，大脑速度计，将 快速检测颅内非常缓慢的大脑运动 与头部创伤有关的出血。该仪器不需要 专家用户，将针对紧急情况的护士和医师员工 医学市场。这种易于使用的低技术超声设备将是 针对全球市场，尤其是在当前的黄金标准的情况下 猫或MR成像是不起作用的。