A Biological Assessment System for Cognitive Persistence

认知持久性的生物评估系统

• 批准号: 6999389
• 负责人: Christopher Hyde
• 金额: $ 24.99万
• 依托单位: BIOASSESSMENTS, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-03 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999389
• 关键词: adolescence (12-20); angiotensin II; attention; attention deficit disorder; behavioral /social science research tag; biomedical equipment development; blood tests; brain circulation; central nervous system stimulants; cerebrovascular imaging /visualization; clinical research; cognition; computer assisted diagnosis; developmental psychology; diagnosis design /evaluation; electrocardiography; heart rhythm; human subject; impulsive behavior; interactive multimedia; mental disorder chemotherapy; mental disorder diagnosis; middle childhood (6-11); psychophysiology; ultrasound blood flow measurement; young adult human (21-34)

DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is a promising biological marker for psychological research. The primary goal of this project is to make the LFCR methodology more accessible to researchers by providing a both a product and extensive support services. In Phase I, a prototype system was built and used to collect simultaneous physiological and cognitive data from 41 elementary school children. The LFCR consistently decreased when children attended to computerized tasks (i.e., under conditions requiring cognitive persistence). In a preliminary pilot study, children with ADHD did not have the same decrease in the LFCR when they attempted to pay attention on the same tasks; however, they did have decreased LFCR after taking their psycho stimulant medication. A secondary goal of this project is to more firmly establish the biological underpinnings of the LFCR. Prior to the Phase I work, angiotensin activity was hypothesized to mediate the relationship between LFCR, cerebral blood flow and cognitive activity. This hypothesis was partially confirmed with the empirical evidence collected in Phase I. Blood assays validated the connection between LFCR and circulating levels of angiotensin. Transcranial Doppler sonography (TCD) data validated that connection between cerebral blood flow and LFCR. These results provide strong empirical support for the proposed biological model of cognitive persistence. This work will be expanded in Phase II through three main tasks. 1) The prototype will be further refined into a user-friendly commercial product. 2) The database of physiological changes in children and adults during cognitive performance will be enlarged using LFCR, TCD, and blood assays (adults only); ADHD participants will be tested before and after taking medication. 3) Strategic collaborations with researchers will be formed to demonstrate the value of the biological measure in other areas of research. Two impediments currently limit the use of LFCR in research studies. First, the biological basis of LFCR was inadequately characterized. The Phase I and II findings will address this limitation. Second, the methodology is too complex for most researchers without expertise in this area. BioAssessments will overcome this impediment by providing both turnkey equipment and extensive support throughout all stages of the research project. The feasibility of this business model will be demonstrated by Phase II collaborations and publications that serve as case studies. The anticipated Phase III customer will be a researcher studying impulsivity in disorders such as Attention Deficit/Hyperactivity Disorder (ADHD) and substance abuse.

描述（由申请人提供）：低频心律（LFCR）是心理学研究的有前途的生物学标记。该项目的主要目标是通过提供产品和广泛的支持服务来使研究人员更容易获得LFCR方法。在第一阶段，建立并用于收集41名小学儿童的同时生理和认知数据。当儿童参加计算机任务时（即在需要认知持久性的条件下），LFCR始终减少。在一项初步的试点研究中，当LFCR试图注意相同任务时，患有多动症的儿童的LFCR没有相同的减少。但是，服用心理刺激药后，他们确实减少了LFCR。该项目的次要目标是更牢固地建立LFCR的生物基础。在第一阶段工作之前，假设血管紧张素活性可以介导LFCR，脑血流和认知活性之间的关系。该假设得到了部分证实，并在第一期中收集的经验证据证实了LFCR与血管紧张素循环水平之间的联系。经颅多普勒超声检查（TCD）数据证实了脑血流与LFCR之间的联系。这些结果为所提出的认知持久性生物学模型提供了强有力的经验支持。这项工作将通过三个主要任务在II阶段扩展。 1）原型将进一步完善用户友好的商业产品。 2）使用LFCR，TCD和血液分析（仅成人），将扩大儿童和成人生理变化的数据库；服用药物之前和之后，ADHD参与者将接受测试。 3）将与研究人员进行战略合作，以证明在其他研究领域中生物学量度的价值。目前有两种障碍限制了LFCR在研究中的使用。首先，LFCR的生物学基础不充分表征。第一阶段和第二阶段的发现将解决此限制。其次，对于大多数在该领域没有专业知识的研究人员而言，该方法学太复杂了。生物评估将通过在研究项目的所有阶段提供交钥匙设备和广泛的支持来克服这一障碍。该业务模型的可行性将通过作为案例研究的第二阶段合作和出版物来证明。预期的III期客户将是一名研究人员，研究了注意力缺陷/多动症（ADHD）和药物滥用等疾病的冲动。