Doppler Ultrasound Automatic Mapping of Basal Cerebral Blood Flow

多普勒超声自动测绘基底脑血流

• 批准号: 7123919
• 负责人: Mark A Moehring
• 金额: $ 72.19万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-19 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123919
• 关键词: brain circulation; brain disorder diagnosis; brain mapping; cerebral artery; clinical research; clinical trials; human subject; model design /development; patient oriented research; phantom model; stroke; technology /technique development; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): This proposal is to develop new Doppler ultrasound technology for automatic diagnostic mapping of blood flow in the basal arteries of the brain. These vessels include the middle cerebral artery, the anterior cerebral artery, and the posterior communicating artery. This technology will enable transcranial Doppler diagnostic workup of the acute stroke patient for the rank-and-file emergency department physician, something not currently possible because of the expertise required to utilize transcranial Doppler in any setting. The Phase I SBIR work, from which this proposal moves forward, successfully demonstrated feasibility of the technology with particularly important demonstration of the fast signal processing algorithms for rapid location of flow signals in the angular territory viewable by the ultrasound beam. This technology is needed to quickly and simply provide diagnosis of pathological blood flow conditions that indicate acute stroke in progress, or the risk of stroke, as well as to selectively apply ultrasound to basal arteries of the brain during thrombolytic therapy for stroke. This technology also presents the potential for dramatically increasing the application to a much wider range of health professionals to obtain important diagnostic information with high sensitivity and specificity, and without the utilization frustrations experienced by current users both in locating and maintaining blood flow signals. The emergency department, the operating room, and the vascular laboratory all represent awaiting markets. Phase II targets significant enhancements to the technology demonstrated in Phase I, including increased angular viewing capability for mapping flow in multiple cerebral vessels. The work proposed will result in a prototype platform to explore a new ultrasound modality from which decisions can be made regarding production prototyping for each of the markets noted above. A device for automatic location of and fast mapping, tracking, and monitoring of blood flow in the basal arteries of the brain represents a major commercial market potential.

描述（由申请人提供）： 该建议是开发新的多普勒超声技术，以自动诊断大脑基础动脉的血流。这些血管包括大脑中动脉，大脑前动脉和后交通动脉。这项技术将使急性中风患者的经颅多普勒诊断检查能够为急诊室医生提供，目前是不可能的，因为在任何情况下都需要使用经颅多普勒的专业知识。该建议从中向前移动的第一阶段SBIR工作成功地证明了该技术的可行性，特别重要地证明了快速信号处理算法，用于在超声波梁可见的角度区域中快速位置流动信号。需要这种技术快速，并简单地诊断出表明正在进行的急性中风或中风的风险以及在溶栓治疗期间选择性地将超声施加到大脑的基础动脉中的病理血流状况。这项技术还介绍了大幅度增加对更广泛的卫生专业人员的应用，以获得具有高灵敏度和特异性的重要诊断信息，并且没有现任用户在定位和维持血流信号方面遇到的利用挫败感。急诊科，手术室和血管实验室都代表着等待市场。 II阶段目标对I阶段证明的技术有显着的增强，包括增加角度的映射流量的角度观看能力。拟议的工作将导致一个原型平台探索一种新的超声模式，可以根据上述每个市场做出关于生产原型制作的决策。用于自动位置和快速映射，跟踪和监测血液流动中大脑基础动脉的设备，代表了主要的商业市场潜力。