Large Animal Facility for Imaging and Image-guided Therapies at MSU

密歇根州立大学用于成像和图像引导治疗的大型动物设施

• 批准号: 10373769
• 负责人: ANNA MOORE
• 金额: $ 672.12万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10373769
• 关键词: Animal Disease Models; Animal Experimentation; Animal Model; Animals; Area; Biomedical Research; Canis familiaris; Cardiovascular Diseases; Client; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Comparative Study; Data; Development; Diabetes Mellitus; Diagnosis; Diagnostic; Disease; Early Diagnosis; Equipment; Family suidae; Funding; Health; Healthcare; Healthcare Systems; Human; Human Biology; Human Pathology; Image; Institution; Laboratory Animals; Length; Link; Longevity; Magnetic Resonance Imaging; Malignant Neoplasms; Medicine; Michigan; Molecular; Molecular Target; New Agents; Outcome; Pathology; Physiology; Play; Positron-Emission Tomography; Precision Health; Pregnancy; Research; Research Personnel; Rodent; Role; Sheep; Small Animal Imaging Systems; Testing; Therapeutic Agents; Training; Translating; Translational Research; Universities; animal facility; animal imaging; bioimaging; clinical imaging; clinical practice; clinically relevant; college; companion animal; comparative; human disease; human model; human subject; image guided; image guided therapy; imaging facilities; imaging system; in vivo imaging; mortality; multidisciplinary; novel therapeutics; pre-clinical; pre-clinical research; precision medicine; programs; success; translational study; undergraduate student

ABSTRACT Precision health is an emerging paradigm in healthcare that focuses on early detection and molecular determinants of disease. Michigan State University (MSU) has launched a University-wide initiative to bring the principles of precision health into its healthcare systems. The success of this initiative depends, in large part, on our ability to obtain relevant data from predictive pre-clinical animal models and effective translational research. Advances in molecularly targeted diagnostic and therapeutic agents, the cornerstones of precision medicine, require reliable testing in informative animal models of human biology. Small laboratory animals (rodents) commonly used in biomedical research are often not suitable for studying pathologies where physiology, human markers, physical size, gestation length, lifespan, and other human-like features are key contributors to disease. Use of larger animal species for research, including dogs, pigs and sheep, can overcome many of these hurdles. It is widely accepted that in vivo imaging plays a pivotal role in nearly all areas of biomedical research and clinical practice, and the importance of its role will only increase with the development of new agents and therapies. However, imaging data obtained in small animal imaging systems cannot always be directly translated to studies in humans. Clearly, studying large animal models using clinical scanners would produce data that are closest to what we expect in humans, and would better inform translational studies. Further, the ability to study comparative diseases that occur spontaneously in domesticated species, as part of clinical studies of client- owned animals, will add further to translational relevance and data outcomes. For these reasons and to advance the clinical relevance of animal models, we are requesting funds to develop a multi-species large animal imaging facility at MSU. This facility will be equipped with a state-of-the-art high-end clinical imaging system (PET/MRI, mMR Biograph, Siemens) that would serve MSU’s diverse biomedical scientific and clinical communities. Researchers will use this facility for studies of large research animals, and client-owned companion animals to develop imaging and image-guided therapy approaches with focus on human pathologies linked to significant mortality rates (e.g., cardiovascular disease, cancer, and diabetes). This multidisciplinary facility will also support ongoing clinical trials in human subjects and serve as a training ground for undergraduate, graduate and postdoctoral trainees from 6 colleges, 12 departments and 7 programs. performing research on a full spectrum of human and animal disease models. This new biomedical imaging facility, in combination with human and veterinary expertise at MSU, creates an extraordinary opportunity to perform pre-clinical, clinical and translational research using clinical imaging equipment. These capabilities will promote high-level collaborations between MSU and investigators at regional and national institutions to ultimately champion and advance a premiere program in precision health and comparative medicine, benefiting both human and animal health in the diagnosis and treatment of disease.

抽象的 Precision Health是医疗保健中新兴的范式，重点是早期检测和分子 疾病的决定因素。密歇根州立大学（MSU）已发起了一项范围 精确健康的原则进入其医疗保健系统。这项倡议的成功在很大程度上取决于 我们从预测性临床前动物模型和有效翻译研究中获取相关数据的能力。 分子靶向诊断和治疗剂的进步，Precision Medicine的基石， 在人类生物学的信息动物模型中需要可靠的测试。小型实验室动物（啮齿动物） 在生物医学研究中通常使用的通常不适合研究生理学，人类的病理学 标记，身体大小，妊娠长度，寿命和其他类似人类的特征是疾病的关键因素。 使用较大的动物物种进行研究，包括狗，猪和绵羊，可以克服许多这些障碍。 人们普遍认为，体内成像在几乎所有生物医学研究领域都起着关键作用 和临床实践以及其角色的重要性只会随着新代理的发展而增加 疗法。但是，在小动物成像系统中获得的成像数据不能总是直接翻译 进行人类研究。显然，使用临床扫描仪研究大型动物模型将产生 最接近我们对人类的期望，并将更好地为翻译研究提供信息。此外，学习能力 作为客户的临床研究的一部分，在驯养物种中自发发生的比较疾病 - 拥有的动物将进一步增加翻译的相关性和数据结果。 由于这些原因并提高了动物模型的临床相关性，我们要求资金 在MSU开发多物种大型动物成像设施。该设施将配备最先进的 高端临床成像系统（PET/MRI，MMR传记，西门子）将为MSU的潜水员服务 生物医学科学和临床社区。研究人员将使用此设施进行大型研究 动物和客户拥有的伴侣动物，以开发成像和图像引导的治疗方法 关注与重大死亡率有关的人类病理（例如，心血管疾病，癌症和 糖尿病）。该多学科设施还将支持人类受试者正在进行的临床试验，并充当 来自6所学院，12个系和7个的本科，研究生和博士后学员的培训场 程序。对全人类和动物疾病模型进行研究。 这种新的生物医学成像设施与MSU的人类和兽医专业知识相结合，创造了 使用临床成像进行临床前，临床和翻译研究的非凡机会 设备。这些功能将促进MSU与区域调查人员之间的高级合作 以及国家机构，最终倡导并推进了精确健康的首映计划 比较医学，使人类和动物健康受益于疾病的诊断和治疗。