Advancement of the Xiphophorus Model for Studying Disease

研究疾病的剑尾动物模型的进展

• 批准号: 10805701
• 负责人: Yuan Lu
• 金额: $ 22.59万
• 依托单位: TEXAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10805701
• 关键词: Address; Adult; Ammonia; Anaerobic Bacteria; Animal Experimentation; Animals; Beds; Behavioral; Bioinformatics; Biological; Biological Models; Biomedical Research; Body Size; Cancer Etiology; Chronobiology; Communities; Cryopreservation; Custom; Data; Development; Disease; Embryo; Ensure; Female; Fishes; Generations; Genetic; Genome; Genomics; Growth; Hybrids; Immunologics; Institution; Lead; Link; Manuals; Mechanics; Metabolism; Mission; National Human Genome Research Institute; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Nitrites; Optics; Parasitology; Personal Satisfaction; Physiological; Plants; Production; Protocols documentation; Regulation; Reproducibility; Reproduction; Research; Resources; Sampling; Services; Shock; Stress; Study models; Swimming; System; Texas; Toxicology; United States National Institutes of Health; Universities; Variant; Water; Xiphophorus; aquarium; bioinformatics resource; density; dietary; genetic resource; improved; inter-individual variation; male; meter; model organism; sex determination; sperm cell; trait; ultraviolet; water flow; water quality; Address; Adult; Ammonia; Anaerobic Bacteria; Animal Experimentation; Animals; Beds; Behavioral; Bioinformatics; Biological; Biological Models; Biomedical Research; Body Size; Cancer Etiology; Chronobiology; Communities; Cryopreservation; Custom; Data; Development; Disease; Embryo; Ensure; Female; Fishes; Generations; Genetic; Genome; Genomics; Growth; Hybrids; Immunologics; Institution; Lead; Link; Manuals; Mechanics; Metabolism; Mission; National Human Genome Research Institute; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Nitrites; Optics; Parasitology; Personal Satisfaction; Physiological; Plants; Production; Protocols documentation; Regulation; Reproducibility; Reproduction; Research; Resources; Sampling; Services; Shock; Stress; Study models; Swimming; System; Texas; Toxicology; United States National Institutes of Health; Universities; Variant; Water; Xiphophorus; aquarium; bioinformatics resource; density; dietary; genetic resource; improved; inter-individual variation; male; meter; model organism; sex determination; sperm cell; trait; ultraviolet; water flow; water quality

Project Summary The Xiphophorus Genetic Stock Center (XGSC) is the only national resource center for the Xiphophorus model system. It provides animals, biological samples, genomics, husbandry, disease and bioinformatics resources to the biomedical research community at large. It resides at Texas State University and has actively served the research community since 1993. Currently, the Xiphophorus are housed in static aquarium of different sizes. While functional, this set up leads to concerns over water quality, and its consistency across different aquariums. Additionally, static water can influence normal Xiphophorus development. We propose to purchase and install a re-circulating system to be used for maintaining and reproducing Xiphophorus to address these issues and aim to improve husbandry conditions for all species housed in the XGSC, in order to strength the rigor and reproducibility of the research animals for the biomedical research community users.

项目摘要 Xiphophorus遗传储备中心（XGSC）是Xiphophorus的唯一国家资源中心 模型系统。它提供动物，生物样品，基因组学，畜牧，疾病和生物信息学 为整个生物医学研究界的资源。它居住在德克萨斯州立大学 自1993年以来积极为研究社区服务。目前，Xiphophorus被安置在静态 不同尺寸的水族馆。在功能中，这是对水质的关注，及其 跨不同水族馆的一致性。此外，静态水会影响正常的Xiphophorus 发展。我们建议购买和安装重新循环系统，用于维护和 再现Xiphophorus来解决这些问题并旨在改善所有物种的饲养条件 为了加强研究动物的严格性和可重复性，以置于XGSC中 生物医学研究社区用户。