Pre-clinical Feasibility Study of Tissue Oxygenation Imager

组织氧合成像仪的临床前可行性研究

• 批准号: 7110029
• 负责人: David John Cuccia
• 金额: $ 9.99万
• 依托单位: MODULATED IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-19 至 2007-08-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7110029
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biosensor device; blood circulation; body water; chronic disease /disorder; diagnosis design /evaluation; hemoglobin; infrared spectrometry; ischemia; laboratory rat; optical tomography; oxygen transport; skin ulcer; surgery; three dimensional imaging /topography; wound healing

DESCRIPTION (provided by applicant): Chronic wounds are non-healing wounds such as diabetic ulcers and pressure ulcers. Each year, 6.5 million cases occur in the U.S., costing the economy billions of dollars. Cost-effective and efficient management of chronic wounds depends on quick assessment and diagnosis of the underlying reasons for compromised healing. Ischemia is 1 of the main complications associated with chronic wounds. Thus, a quantitative method to assess and monitor tissue oxygenation and perfusion status of chronic wounds can be an indispensable tool for prevention and cost-effective management of chronic wounds. In this STTR phase I proposal, we test the ability of a newly developed near-infrared imaging method called modulated imaging as a non-contact wound perfusion and oxygenation imager. 2 main features of the modulated imaging device are (a) its capability to provide 2D topographic maps of hemoglobin concentrations and oxygen saturation, and (b) its depth-sectioning capability to provide 3D tomographic images. In this study, these features are tested on an animal wound model that simulates chronic wounds undergoing ischemia. Specific aims are to (1) implement ischemic skin flaps in rats to simulate chronic wounds with compromised tissue oxygenation and perfusion; (2) Acquire full range of multi-spectral, multi- spatial-frequency images of skin flaps before and after surgery; (3) process and optimize images for 2D/3D mapping of hemoglobin concentrations, oxygen saturation, and water content in superficial wound. The results of this work will provide essential design for building a dedicated prototype imaging oximeter system for evaluating clinical wounds in Phase II.

描述（由申请人提供）：慢性伤口是糖尿病性溃疡和压溃疡等非治疗伤口。每年，在美国发生了650万例案件，耗资数十亿美元。慢性伤口的成本效益有效管理取决于对愈合受损的基本原因的快速评估和诊断。缺血是与慢性伤口有关的主要并发症之一。因此，一种评估和监测慢性伤口组织氧合和灌注状态的定量方法可能是预防和具有成本效益的慢性伤口管理的必不可少的工具。在此STTR I期建议中，我们测试了新开发的近红外成像方法称为调制成像作为非接触式伤口灌注和氧合成像仪的能力。调制成像设备的2个主要特征是（a）其能够提供2D地形图的血红蛋白浓度和氧饱和度的能力，以及（b）其深度切片能力提供3D断层扫描图像。在这项研究中，这些特征在动物伤口模型上进行了测试，该模型模拟了患缺血的慢性伤口。具体目的是（1）在大鼠中实现缺血性皮瓣，以模拟组织氧合和灌注受损的慢性伤口； （2）在手术前后，获得皮肤皮瓣的多光谱多光谱，多频； （3）在浅表伤口中的血红蛋白浓度，氧饱和度和水含量的2D/3D映射的过程和优化图像。这项工作的结果将为建立专用原型成像血氧仪系统提供必不可少的设计，以评估II期临床伤口。