The Development of a Low-Cost, Quantitative Skin Imaging Camera

低成本定量皮肤成像相机的开发

• 批准号: 9256129
• 负责人: David John Cuccia
• 金额: $ 87.44万
• 依托单位: MODULATED IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-15 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9256129
• 关键词: Abate; Algorithms; Archives; Biochemical; Biological; Blood Vessels; Blood Volume; California; Caring; Chronic Disease; Clinical; Clinical Management; Clinical Research; Color; County; Critical Pathways; Data; Decubitus ulcer; Dermatologic; Dermatology; Development; Devices; Diabetes Mellitus; Diabetic Foot Ulcer; Digital Photography; Documentation; Economics; Epidemic; Evaluation; Funding; Goals; Grant; Hand; Health; Image; Imagery; Imaging Device; Imaging Techniques; Imaging technology; Intuition; Lighting; Maps; Measures; Melanins; Modeling; Monitor; Morphologic artifacts; Motion; Multi-Institutional Clinical Trial; Oranges; Output; Pattern; Performance; Perfusion; Phase; Photography; Physiological; Play; Population; Prevention; Primary Health Care; Quality of Care; Quality of life; Research; Research Proposals; Risk; Role; Skin; Small Business Innovation Research Grant; Spatial Frequency Domain Imaging; Standardization; Structure; Surface; System; Tablet Computer; Tablets; Technology; Testing; Time; Tissue imaging; Tissues; Underserved Population; Universities; Validation; Visualization software; Water; Work; aging population; base; chromophore; chronic wound; clinical research site; cost; data acquisition; deoxyhemoglobin; design; digital; experience; imaging modality; imaging system; in vivo; innovation; instrumentation; light weight; mortality; optical imaging; point of care; pre-clinical; programs; prototype; screening; tissue oxygenation; validation studies; verification and validation; wound

Abstract Management of chronic wounds are a burden in today’s aging population. Expert wound care is needed to monitor and track skin health. Advances in digital photography have made it an efficient and economic option for surveillance and treatment. However, even with the best of circumstances, photographs typically provide qualitative color information that the clinician will interpret to assess physiological tissue health. Recent advancements in optical imaging methods and devices offer the ability to perform quantitative characterization of tissue structure and biochemical status. Modulated Imaging (MI), also known as Spatial Frequency Domain Imaging (SFDI) employs multispectral, patterned illumination to non-invasively obtain subsurface images of biological tissue. The broad goal of this research proposal is to build and validate a handheld system that brings MI technology to point-of-care (PoC) applications. This “PoC-MI” device will dramatically simplify system complexity and size, while utilizing primarily off-the-shelf consumer-grade components. Based on research accomplishments in Phase I, we have identified hardware and algorithms that will enable us to build a PoC-MI device at lower cost (~10x BOM reduction), lighter weight (~10x lighter), and with faster acquisition (0.1 ms, ~100-1000x faster) compared to previous revisions of the technology. In this Phase II proposal, we propose to design and fabricate a low-cost, hand-held tablet form factor, quantitative skin imaging camera with careful assessment of device performance on tissue-simulating phantoms and performance validation in well-established pre-clinical and clinical models. The results of this grant will be the first PoC MI system that provides quantitative biochemical information of the skin into a tablet form factor, enabling wide applicability in clinical management of chronic wounds.

抽象的 慢性伤口的管理是当今人口老龄化的伯宁。专家伤口护理是 需要监测和跟踪皮肤健康。数码摄影的进步使它成为了 进行监视和治疗的高效和经济选择。但是，即使有最好的 情况，照片通常提供临床将会提供的定性颜色信息 解释以评估物理组织健康。光学成像的最新进展 方法和设备具有执行组织结构定量表征的能力 和生化状态。调制成像（MI），也称为空间频域 成像（SFDI）员工多光谱，非侵入性获得的图案照明 生物组织的地下图像。该研究建议的广泛目标是建立和 验证将MI技术带入现行点（POC）应用的手持系统。这 “ POC-MI”设备将大大简化系统的复杂性和尺寸，同时使用主要 现成的消费级组件。根据第一阶段的研究成就，我们 已经确定了硬件和算法，这些硬件和算法将使我们能够在较低的 成本（减少10倍），重量轻（轻度〜10倍），并且采购速度更快（0.1 ms， 与以前的技术修订相比，〜100-1000倍。在此第二阶段提案中， 我们建议设计和制造低成本，手持式平板电脑外形，定量皮肤 成像摄像机，并仔细评估组织模拟幻像的设备性能 以及良好的临床前和临床模型中的性能验证。结果 该赠款将是第一个提供定量生化信息的POC MI系统 皮肤成为平板电脑的外形，从而在慢性的临床管理中广泛适用 伤口。