HIGH RESOLUTION AND ROUTINE SERVICE MASS SPECTROMETERS

高分辨率和常规服务质谱仪

• 批准号: 3521312
• 负责人: YOSHITO KISHI
• 金额: $ 40万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-21 至 1992-05-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3521312
• 关键词: biomedical equipment purchase; chemical structure; chemical synthesis; mass spectrometry

The Department of Chemistry at Harvard University requests funds for the acquisition of two mass spectrometers. The first will be a high-performance, high-resolution mass spectrometer with electron impact (EI), chemical ionization, (CI) and fast atom bombardment (FAB) ionization capabilities; this instrument will be operated by trained operators. The second will be a general purpose instrument open to use by all qualified users. A core group of six faculty and their research teams will use these new instruments to characterize complex organic compounds. Research conducted by this group includes the synthesis of biologically active substances (such as prostaglandins, leukotrienes, thromboxanes, blood group substances, immunostimulators, antibiotics, antiviral agents, polypeptides, sugars, hormones and nucleic acids) and the determination of structures of natural products and synthetic intermediates.

哈佛大学化学系请求资助 购置两台质谱仪。 第一个将是 具有电子轰击功能的高性能、高分辨率质谱仪 (EI)、化学电离、(CI) 和快原子轰击 (FAB) 电离能力；该仪器将由经过培训的人员操作 运营商。 第二个将是开放使用的通用仪器 所有合格用户。 由六名教师组成的核心团队及其研究 团队将使用这些新仪器来表征复杂的有机物 化合物。 该小组进行的研究包括合成 生物活性物质（如前列腺素、白三烯、 血栓素、血型物质、免疫刺激剂、抗生素、 抗病毒剂、多肽、糖、激素和核酸）和 天然产物和合成产物的结构测定 中间体。