SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS

复杂天然产品的综合研究

• 批准号: 2431108
• 负责人: YOSHITO KISHI
• 金额: $ 60.62万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2431108
• 关键词: batrachotoxins; biological products; blood group antigens; chemical structure; chemical structure function; chemical synthesis; conformation; glycosides; lipopolysaccharides; neurotoxins; polysaccharides; stereoisomer; toxin

DESCRIPTION: In this renewal proposal it is stated that the major objective in this research is to make significant contributions to organic chemistry and medicine through synthetic studies on physiologically active natural and man-made organic compounds, including 1. Palytoxin: Total Synthesis, Preferred Local and Global Conformation, Preparation of Radioactively Labelled PTX, and Preparation of Affinity Column, 2. Conformational Analysis of C- and O- Glycosides: Human Blood antigens, 6-O-Methyl-D-glucose containing Lipopolysaccharides (MGLP) and 3-O-methylmannose-containing Polysaccharides (MMP), and C-Trehaloses, 3. Chemical Ruler: Conformational Analysis of Fatty Acids and Their Derivatives; Design and Synthesis of Large Organic Molecules with Ion Channel-like Assemblies; Stereochemistry Assignment of Maitotoxin, 4. Structure Elucidation and Synthesis of AAL toxins and Fumonisins, 5. Ni(II)/Cr(II)-Mediated Coupling Reaction: Asymmetric Process, 6. Tripodal Ligand Chemistry: Enterobactin analogs and others, and 7. Total Synthesis of Batrachotoxin and Aranotin. The principal investigator notes that the power of organic chemistry is most effectively extended by challenging complex systems, and much of the progress of medicine critically depends upon the extension of the power of organic chemistry. He further states that it is also his specific objective to develop practical and efficient syntheses of certain natural products and their analogs which have high physiological activity, but are not available in appreciable amounts from natural sources. He expects that these studies are to stimulate progress in medicine.

描述：在此更新提案中指出，主要 这项研究的目标是做出重大贡献 有机化学和医学通过综合研究 具有生理活性的天然和人造有机化合物，包括 1.水藻毒素：全合成，优选局部和整体构象， 放射性标记的PTX的制备和亲和力的制备 专栏 2. C- 和 O- 糖苷的构象分析：人血 抗原、含有脂多糖 (MGLP) 的 6-O-甲基-D-葡萄糖和 含 3-O-甲基甘露糖的多糖 (MMP) 和 C-海藻糖， 3. 化学尺：脂肪酸及其构象分析 衍生品；离子有机大分子的设计与合成 通道状组件；麦芽毒素的立体化学分配，4。 AAL毒素和伏马菌素的结构解析和合成，5。 Ni(II)/Cr(II) 介导的偶联反应：不对称过程，6。 三足配体化学：肠杆菌素类似物和其他，7。 箭毒毒素和阿诺丁的全合成。 校长 研究人员指出，有机化学的力量是最强大的 通过挑战复杂的系统来有效地扩展，并且许多 医学的进步关键取决于权力的扩展 有机化学。 他进一步指出，这也是他的具体 目标是开发某些实用且有效的合成方法 具有高生理活性的天然产物及其类似物 活性，但不能从自然中获得大量的 来源。 他希望这些研究能够推动相关领域的进步 药品。