SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS

抗肿瘤天然产物的合成

• 批准号: 6137377
• 负责人: YOSHITO KISHI
• 金额: $ 44.83万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-03-17 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6137377
• 关键词: analog; anthracyclines; antineoplastics; biological products; daunorubicin; drug design /synthesis /production; lactams; paclitaxel; tumor promoters

The major objective of this research is to make significant contributions to organic chemistry and medicine through studies directed towards the synthesis of natural products with antitumor activity or tumor-promoting activity, including halichondrins, C-indolactam V, cytoblastin, taxol/cephalomannine, mycalamides/onnamide, and daunomycin analogs. We believe that the power of organic chemistry, especially organic synthesis, is most effectively extended by challenging complex systems, and much of the progress of medicine certainly depends upon extension of the power of chemistry. More specifically, research efforts will be made first to develop general, flexible, and efficient syntheses of certain natural products and then to apply these to the synthesis of their analogs and derivatives, whose study will provide clues for developing better antitumor drugs or for understanding the tumor-promoting process. Among the five programs proposed, the halichondrin project is most advanced in our quest for an antitumor drug, and research plans are presented to identify a drug candidate for further clinical development.

这项研究的主要目的是做出重大贡献 通过针对有机化学和医学 具有抗肿瘤活性或肿瘤促进的天然产物的合成 活性，包括alichondrins，C- Indolactam V，Cytoblastin， 紫杉醇/头孢藻氨氨氨酸，霉菌胺/on nemide和daunomycin类似物。 我们 相信有机化学的力量，尤其是有机合成的力量， 最有效地通过挑战复杂系统和大部分 医学的进展当然取决于扩展的力量 化学。 更具体地说，将首先进行研究工作 发展某些自然的一般，灵活和有效的合成 产品，然后将其应用于其类似物的合成和 衍生品的研究将为发展更好 抗肿瘤药物或用于理解肿瘤促进过程。 之中 提出的五个计划，哈利金德林项目最先进 我们寻求抗肿瘤药物，并提出了研究计划 确定候选药物以进行进一步的临床发育。