SYNTHESIS OF ANTITUTMOR NATURAL PRODUCTS

抗肿瘤天然产物的合成

• 批准号: 3481913
• 负责人: YOSHITO KISHI
• 金额: $ 31.09万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-03-17 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3481913
• 关键词: anthracyclines; antineoplastic antibiotics; antineoplastics; daunorubicin; drug design /synthesis /production; drug metabolism; neoplasm /cancer pharmacology; paclitaxel; tumor promoters

The major objective of this research is to make significant contributions to organic chemistry and medicine through studies directed towards the synthesis of natural products with antitumor activity or tumor-promoter activity, including daunomycin-aclacinomycin analogs, nogalamycin, aplysiatoxins, teleocidins, diacylglycerol analogs, and taxol-cephalomannine. We believe that the power of organic chemistry, especially organic synthesis, is most effectively extended by challenging complex systems, and much of the progress of medicine certainly depends upon extension of the power of chemistry. More specifically, research efforts will be made first to develop general, flexible and efficient syntheses of certain natural products and then to apply these to the synthesis of their analogs and derivatives, whose study will provide clues for developing better antitumor drugs or for understanding the tumor-promoting process.

这项研究的主要目标是做出重大贡献 通过针对有机化学和医学的研究 具有抗肿瘤活性或促肿瘤活性的天然产物的合成 活性，包括道诺霉素-阿拉霉素类似物、诺加霉素、 海兔毒素、远杀素、二酰基甘油类似物，以及 紫杉醇-三尖杉宁碱。 我们相信有机化学的力量， 特别是有机合成，通过挑战最有效地扩展 复杂的系统，医学的进步很大程度上取决于 化学力量的扩展。 更具体地说，研究 首先着力发展通用、灵活、高效 合成某些天然产物，然后将其应用于 其类似物和衍生物的合成，其研究将提供线索 为了开发更好的抗肿瘤药物或了解 肿瘤促进过程。