SYNTHESIS OF ANTITUMOR NATURAL PRODUCTS

抗肿瘤天然产物的合成

• 批准号: 3165775
• 负责人: YOSHITO KISHI
• 金额: $ 20.08万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-03-01 至 1986-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3165775
• 关键词: anthracyclines; antineoplastic antibiotics; doxorubicin; drug adverse effect; drug design /synthesis /production; mitomycins; neoplasm /cancer chemotherapy; neurotoxins

The major objective of this research is to make significant contributions to organic chemistry and medicine through synthetic studies of natural products with antitumor activity, including mitomycins, aclacinomycins, aplysiatoxins, macbecin, phyllanthocin, and bruceantin. We believe that the power of organic synthesis can be most effectively extended by challenging such complex synthetic targets. Much of the progress in medicine depends upon the extension of this power of organic chemistry. It is also our specific objective to develop general, efficient and practical syntheses of certain natural products which have promising antitumor activity but which are not available in appreciable amounts from natural sources, and then apply them to the synthesis of their analogs and derivatives with the hope that some will exhibit improved therapeutic ratios.

这项研究的主要目标是做出重大贡献 通过天然产物的合成研究进行有机化学和医学 具有抗肿瘤活性，包括丝裂霉素、阿克拉霉素、海兔毒素、 麦克菌素、叶花素和布鲁斯汀。 我们相信有机的力量 通过挑战这种复杂的合成可以最有效地扩展合成 目标。 医学上的进步很大程度上取决于这种能力的扩展 有机化学的力量。 开发通用的、高效的、实用的也是我们的具体目标 某些具有良好抗肿瘤活性的天然产物的合成 但从天然来源中无法获得大量，并且 然后将它们应用于其类似物和衍生物的合成，希望 有些将表现出改善的治疗率。