SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS

复杂天然产品的综合研究

• 批准号: 2891553
• 负责人: YOSHITO KISHI
• 金额: $ 65.55万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-06-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891553
• 关键词: batrachotoxins; biological products; blood group antigens; chemical structure; chemical structure function; chemical synthesis; conformation; glycosides; lipopolysaccharides; neurotoxins; polysaccharides; stereoisomer; toxin

DESCRIPTION: In this renewal proposal it is stated that the major objective in this research is to make significant contributions to organic chemistry and medicine through synthetic studies on physiologically active natural and man-made organic compounds, including 1. Palytoxin: Total Synthesis, Preferred Local and Global Conformation, Preparation of Radioactively Labelled PTX, and Preparation of Affinity Column, 2. Conformational Analysis of C- and O- Glycosides: Human Blood antigens, 6-O-Methyl-D-glucose containing Lipopolysaccharides (MGLP) and 3-O-methylmannose-containing Polysaccharides (MMP), and C-Trehaloses, 3. Chemical Ruler: Conformational Analysis of Fatty Acids and Their Derivatives; Design and Synthesis of Large Organic Molecules with Ion Channel-like Assemblies; Stereochemistry Assignment of Maitotoxin, 4. Structure Elucidation and Synthesis of AAL toxins and Fumonisins, 5. Ni(II)/Cr(II)-Mediated Coupling Reaction: Asymmetric Process, 6. Tripodal Ligand Chemistry: Enterobactin analogs and others, and 7. Total Synthesis of Batrachotoxin and Aranotin. The principal investigator notes that the power of organic chemistry is most effectively extended by challenging complex systems, and much of the progress of medicine critically depends upon the extension of the power of organic chemistry. He further states that it is also his specific objective to develop practical and efficient syntheses of certain natural products and their analogs which have high physiological activity, but are not available in appreciable amounts from natural sources. He expects that these studies are to stimulate progress in medicine.

描述：在此续签建议中，指出专业 这项研究的目的是为 有机化学和医学通过合成研究 生理活性的天然和人造有机化合物，包括 1。呼毒素：总合成，首选局部和全球构象， 制备放射性标记的PTX和亲和力的准备 第2列。C-和O-糖苷的构象分析：人类血液 抗原，含有脂多糖（MGLP）的6-O-甲基-D-葡萄糖和 3-O-甲基甘露糖的多糖（MMP）和C-Trehalose， 3。化学统治者：脂肪酸及其它们的构象分析 衍生物；与离子的大型有机分子的设计和合成 类似频道的组件； Maitotoxin的立体化学分配，4。 AAL毒素和烟素的结构阐明和合成5。 Ni（II）/CR（II）介导的偶联反应：非对称过程，6。 三座配体化学：肠乳类似物等，以及7。 巴氏毒素和芳香蛋白的总合成。 校长 研究者指出，有机化学的力量最多 有效地通过挑战复杂系统和许多 医学的进展严重取决于力量的扩展 有机化学。 他进一步指出，这也是他的具体 建立某些实用和有效合成的目的 天然产品及其具有高生理的类似物 活动，但没有自然的可观数量 来源。 他希望这些研究将刺激进步 药品。