MALDI-TOF MS for Carbohydrate and Glycoconjugate Studies

用于碳水化合物和糖复合物研究的 MALDI-TOF MS

• 批准号: 6580642
• 负责人: RON ORLANDO
• 金额: $ 28.04万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580642
• 关键词: biomedical equipment purchase; carbohydrate structure; carbohydrates; cell cycle; cell growth regulation; chemical synthesis; endotoxins; glycolipids; glycoproteins; glycosylation; gram negative bacteria; hormone receptor; human immunodeficiency virus; inhibitor /antagonist; mass spectrometry; neoplastic process; selenoprotein; virulence; virus protein

DESCRIPTION (provided by applicant): The Complex Carbohydrate Research Center (CCRC) at The University of Georgia (UGA) proposes to purchase a matrix-assisted laser desorption/ionization-time of flight mass spectrometer (MALDI-TOF MS) with support from the Shared Instrumentation Grant program of the National Institutes of Health. The instrument will be utilized by all faculty and senior scientific staff members of the CCRC and other faculty at UGA for the study of complex carbohydrates and glycoconjugates, including the following research projects: 1. Structural Characterization of Cell Surface Carbohydrate Virulence Factors from Gram-Negative Bacteria 2. Synthesis and Biological Evaluation of Novel Endotoxin Antagonists 3. Understanding the Regulation of Cell Cycle Transitions 4. Identification of HIV-Encoded Selenoproteins 5. Glucosylation Changes and Cancer Progression 6. Identification of Hormone-Receptor Contact Sites by MALDI-TOF MS

描述（由申请人提供）：佐治亚大学 (UGA) 的复杂碳水化合物研究中心 (CCRC) 提议在美国国立卫生研究院的共享仪器资助计划。该仪器将由 CCRC 的所有教职人员和高级科学人员以及 UGA 的其他教职人员用于复杂碳水化合物和糖复合物的研究，包括以下研究项目： 1. 革兰氏阴性细胞表面碳水化合物毒力因子的结构表征细菌 2. 新型内毒素拮抗剂的合成和生物学评价 3. 了解细胞周期转变的调节 4. HIV 编码的鉴定硒蛋白 5. 糖基化变化和癌症进展 6. 通过 MALDI-TOF MS 鉴定激素受体接触位点