Interrogating the extremes of skeletal muscle plasticity in vertebrates

探究脊椎动物骨骼肌可塑性的极限

• 批准号: DP240102721
• 负责人: Prof Gordon Lynch
• 金额: $ 35.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102721
• 关键词: Interrogating; extremes; skeletal; muscle; plasticity

This project aims to interrogate how muscles adapt to growth and endurance stimuli at different stages of life, relevant to addressing challenges facing the world’s ageing population. Using innovative gene technologies and molecular physiology in zebrafish and mice, this project will answer important, unresolved questions in muscle biology. The project will generate knowledge needed to develop interventions to improve quality of life for older Australians and address the physical realities of an ageing workforce. Benefits extend to enhancing workplace safety and productivity, improving farming efficiencies for livestock and aquaculture industries, and training emerging leaders in the biological sciences.

该项目旨在询问肌肉如何在生活的不同阶段适应肌肉的成长和耐力刺激，这与应对世界老年人口所面临的挑战有关。该项目使用创新的基因技术和分子生理学，该项目将回答肌肉生物学中重要的，未解决的问题。该项目将产生开发干预措施以改善澳大利亚老年人生活质量的知识，并解决老龄化劳动力的身体现实。益处扩大了工作场所的安全性和生产力，提高了牲畜和水产养殖行业的农业效率，并培训了生物科学领域的新兴领导者。