Age-related mechanisms of amino acid signalling in skeletal muscle

骨骼肌氨基酸信号传导的年龄相关机制

• 批准号: DP190101937
• 负责人: Prof Gordon Lynch
• 金额: $ 35.04万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101937
• 关键词: Age; related; mechanisms; amino; acid

This project aims to increase our understanding of the role of glycine receptor-mediated signalling and its metabolism in the amino acid sensing capacity of mTORC1, a key enzyme regulating muscle protein synthesis. Ageing is associated with a progressive decline in skeletal muscle mass, weakness, and impaired regeneration after injury. Impaired anabolic signalling after food intake has been proposed as a key contributor, yet the metabolic pathways responsible for nutrient sensing and regulation of protein synthesis remain unresolved. The project will assess defective amino acid sensing and protein synthesis in old mammals, identifying the role of glycine signalling in these processes. The project expects to underpin development of muscle-specific modulators of muscle homeostasis with broad relevance to Australia’s ageing population.

该项目旨在提高我们对甘氨酸受体介导的信号传导的作用及其代谢在MTORC1的氨基酸敏感性能力中的作用，MTORC1是一种关键的酶调节性肌肉蛋白的合成。衰老与受伤后骨骼肌质量，无力和再生受损的逐渐下降有关。已提出食物摄入后的合成代谢信号传导作为关键贡献者，但是负责营养感应和调节蛋白质合成的代谢途径仍未解决。该项目将评估旧哺乳动物中有缺陷的氨基酸传感和蛋白质合成，并确定甘氨酸信号在这些过程中的作用。该项目预计将为肌肉体内平衡的肌肉特异性调节剂提供支持，并与澳大利亚的老龄化人口相关。