Modulating heat shock protein expression in skeletal muscle to improve the pathophysiology of muscular dystrophy

调节骨骼肌中的热休克蛋白表达以改善肌营养不良症的病理生理学

• 批准号: nhmrc : 1009114
• 负责人: Prof Gordon Lynch
• 金额: $ 33.5万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulating-heat-shock-muscular-dystrophy/109373
• 关键词: Modulating; heat; shock; protein; expression

Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. Dystrophic muscles are fragile, prone to injury, and regenerate poorly after damage. Defective calcium handling has been implicated in these processes. We have revealed that upregulating levels of stress proteins called _heat shock proteins� (HSPs) can improve calcium regulation in muscular dystrophy. Modulating the HSP response has significant potential to delay the onset or slow the progression of DMD.

Duchenne肌肉营养不良（DMD）是肌肉营养不良的最常见和严重形式。营养不良的肌肉脆弱，容易受伤，损伤后再生较差。在这些过程中，钙处理有缺陷。我们已经透露，称为_热休克蛋白（HSP）的应激蛋白的上调水平可以改善肌肉营养不良的钙调节。调节HSP响应具有延迟发作或减慢DMD进展的显着潜力。