Understanding the cellular cues that direct muscle stem cell specification

了解指导肌肉干细胞规范的细胞线索

• 批准号: DP150100206
• 负责人: Prof Gordon Lynch
• 金额: $ 51.53万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100206
• 关键词: Understanding; cellular; cues; direct; muscle

The project aims are to identify the metabolic factors that regulate muscle stem cell identity and to examine how changes in the local metabolic environment can influence how stem cells respond to biological perturbations. One of the most important and unresolved issues in skeletal muscle biology is understanding the role of muscle stem cells in the regulation of growth and development, adaptation and plasticity. We have identified that the local skeletal muscle metabolic milieu may regulate the activity of skeletal muscle stem cells. This project could reveal novel mechanisms by which skeletal muscle stem cells can be regulated. This information is crucial for our fundamental understanding of stem cell biology and its future applications.

该项目的目的是确定调节肌肉干细胞身份的代谢因素，并检查局部代谢环境中的变化如何影响干细胞对生物扰动的反应。骨骼肌生物学中最重要和未解决的问题之一是了解肌肉干细胞在调节生长和发育，适应和可塑性中的作用。我们已经确定局部骨骼肌代谢环境可能调节骨骼肌干细胞的活性。该项目可以揭示可以调节骨骼肌干细胞的新机制。该信息对于我们对干细胞生物学及其未来应用的基本理解至关重要。