Regulating calcium handling in skeletal muscle - implications for muscle contraction, injury and repair, ageing and development

调节骨骼肌中的钙处理——对肌肉收缩、损伤和修复、衰老和发育的影响

• 批准号: DP0772781
• 负责人: Prof Gordon Lynch
• 金额: $ 20.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0772781
• 关键词: Regulating; calcium; handling; skeletal; muscle; Regulating; calcium; handling; skeletal; muscle

Understanding the mechanisms regulating calcium in skeletal muscle has important relevance for studying muscle growth and development, injury and repair, and for identifying therapeutic targets and potential therapies for ageing-related disorders, reconstructive surgery, sporting and workplace injuries, and muscle diseases. Combining cell physiology, fluorescence microscopy and digital imaging technologies for studying multicellular tissues such as skeletal muscle will enhance the international competitiveness of Australian biological research. The research will optimise development of gene delivery systems that may find eventual application for muscle wasting disorders and conditions where muscle weakness compromises quality of life.

了解调节骨骼肌钙的机制对于研究肌肉生长和发育，损伤和修复以及确定与老年相关疾病，重建手术，体育和工作场所伤害以及肌肉疾病的治疗靶点和潜在疗法具有重要意义。结合细胞生理，荧光显微镜和数字成像技术，用于研究多细胞组织，例如骨骼肌，将增强澳大利亚生物学研究的国际竞争力。该研究将优化基因输送系统的开发，这些系统可能会发现肌肉浪费障碍和肌肉无力损害生活质量的情况。