Therapeutic potential of modulating heat shock protein expression for muscle wasting disorder

调节热休克蛋白表达对肌肉萎缩症的治疗潜力

• 批准号: nhmrc : 1065456
• 负责人: Prof Gordon Lynch
• 金额: $ 78.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-potential-modulating-wasting-disorder/455170
• 关键词: Therapeutic; potential; modulating; heat; shock; Therapeutic; potential; modulating; heat; shock

Heat shock proteins help stressed proteins fold back to their original conformation and restore function. In a discovery published in Nature we identified induction of heat shock protein 72 (Hsp72) as a novel approach for muscular dystrophy and other conditions where there is inflammation and muscle weakness. This proposal will investigate whether Hsp72 induction is similarly effective in tackling the muscle wasting and weakness in conditions like ageing and frailty and in muscle injury.

热休克蛋白有助于胁迫蛋白质折叠回其原始构象和恢复功能。在自然界发表的发现中，我们确定了热休克蛋白72（HSP72）是一种肌肉营养不良的新方法，以及其他患有炎症和肌肉无力的疾病。该提案将调查HSP72诱导是否在衰老，脆弱以及肌肉损伤等条件下诱导HSP72诱导是否同样有效。